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Breast Cancer Research and Treatment

, Volume 147, Issue 1, pp 221–222 | Cite as

Haste makes waste: Are the data regarding TARGIT-A IORT ready for prime time?

  • Orit Kaidar-PersonEmail author
  • Philip Poortmans
  • Suzanne Klimberg
  • Joanne Haviland
  • Birgitte Offersen
  • Riccardo Audisio
  • John Yarnold
Letter to the Editor
  • 209 Downloads

We would like to comment on the manuscript written by Esserman and colleagues [1] regarding the application of a decision analytic framework for adoption of clinical trial results. It is true that due to the prevalence of breast cancer, any management decision concerning its treatment may have significant implications concerning medical resources use and costs. However, this also holds true for any mistake or hasty decision that might carry a heavy price on public health in the long term.

If the purpose of the model presented in the article aimed to describe an analytic framework, then for the purpose of proof of concept, the statistical analysis should be applied first on treatments for which long-term follow-up is available, in order to prove and validate that the model can predict the same results as in the reality of daily practice. The use of the currently available TARGIT-A trial data to evaluate this model is inappropriate since follow-up in the TARGIT-A trial is immature [2, 3]...

Keywords

High Local Recurrence Rate Adjuvant Hormonal Treatment Hasty Decision Staff Safety Decision Analytic Framework 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Conflict of interest

None.

References

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Orit Kaidar-Person
    • 1
    Email author
  • Philip Poortmans
    • 2
  • Suzanne Klimberg
    • 3
    • 4
    • 5
  • Joanne Haviland
    • 6
  • Birgitte Offersen
    • 7
  • Riccardo Audisio
    • 8
  • John Yarnold
    • 9
  1. 1.Division of OncologyRambam Health Care CampusHaifaIsrael
  2. 2.Institute VerbeetenTilburgThe Netherlands
  3. 3.Division of Breast Surgical Oncology, Department of Surgery, Winthrop P Rockefeller Cancer InstituteUniversity of Arkansas for Medical Sciences (UAMS)Little RockUSA
  4. 4.Arkansas Breast Cancer Research Program (ABCRP), Winthrop P Rockefeller Cancer InstituteUniversity of Arkansas for Medical Sciences (UAMS)Little RockUSA
  5. 5.Department of PathologyUniversity of Arkansas for Medical SciencesLittle RockUSA
  6. 6.Faculty of Health SciencesUniversity of SouthamptonSouthamptonUK
  7. 7.Department of OncologyAarhus University HospitalAarhusDenmark
  8. 8.St Helens Teaching HospitalUniversity of LiverpoolSt HelensUK
  9. 9.Division of Radiotherapy and ImagingThe Institute of Cancer ResearchLondonUK

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