Breast Cancer Research and Treatment

, Volume 144, Issue 2, pp 379–389

Determinants of genetic counseling uptake and its impact on breast cancer outcome: a population-based study

  • Aurélie Ayme
  • Valeria Viassolo
  • Elisabetta Rapiti
  • Gérald Fioretta
  • Hyma Schubert
  • Christine Bouchardy
  • Pierre O. Chappuis
  • Simone Benhamou
Epidemiology

Abstract

Genetic counseling and BRCA1/BRCA2 genes testing are routinely offered in a clinical setting. However, no data are available on the proportion of breast cancer patients with a positive family history undergoing genetic counseling. By linking databases of the Oncogenetics and Cancer Prevention Unit at the Geneva University Hospitals and the population-based Geneva Cancer Registry, we evaluated the uptake of genetic counseling among 1709 breast cancer patients with familial risk of breast cancer and the determinants of such a consultation process. We also studied the impact of genetic counseling on contralateral breast cancer occurrence and survival. Overall, 191 (11.2 %) breast cancer patients had genetic counseling; this proportion was 25.1 % within the high familial risk group. Recent period of diagnosis, early-onset breast cancer, female offspring, high familial risk, tumor size, and chemotherapy treatment were statistically significantly associated with genetic counseling uptake in multivariate analysis. More than 2 % of patients had developed contralateral metachronous breast cancer. An increased risk of contralateral breast cancer of borderline significance was found for patients who had genetic counseling versus those who had not (Cox model adjusted hazard ratio 2.2, 95 % confidence intervals 1.0–5.2, P = 0.063). Stratification by BRCA1/BRCA2 mutation status showed that the occurrence of contralateral breast cancer was 8-fold higher among mutation carriers compared with non-carriers. Age-adjusted overall survival and breast cancer-specific survival were not significantly different between patients who underwent genetic counseling and those who did not. In conclusion, we observed a significant increase in the use of genetic counseling over time and found that breast cancer patients with high familial risk had more often genetic counseling than those with moderate familial risk. A more thorough evaluation of sociodemographic and clinical predictors to attend the cancer genetic unit may help improving the use of genetic counseling services for at-risk individuals at a population level.

Keywords

Breast cancer Familial Genetic counseling Second primary Epidemiology Cancer 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Aurélie Ayme
    • 1
    • 2
  • Valeria Viassolo
    • 2
  • Elisabetta Rapiti
    • 3
  • Gérald Fioretta
    • 3
  • Hyma Schubert
    • 3
  • Christine Bouchardy
    • 3
  • Pierre O. Chappuis
    • 2
    • 4
  • Simone Benhamou
    • 3
    • 5
  1. 1.Department of Genetic and Laboratory MedicineUniversity Hospitals of GenevaGenevaSwitzerland
  2. 2.Oncogenetics and Cancer Prevention Unit, Division of OncologyUniversity Hospitals of GenevaGeneva 14Switzerland
  3. 3.Geneva Cancer Registry, Institute for Social and Preventive MedicineGeneva UniversityGenevaSwitzerland
  4. 4.Division of Genetic MedicineUniversity Hospitals of GenevaGeneva 4Switzerland
  5. 5.INSERM, U946ParisFrance

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