Breast Cancer Research and Treatment

, Volume 143, Issue 3, pp 605–607 | Cite as

Steroid hormone receptor expression in breast cancer stroma

  • Mary E. Booth
  • Andrew M. Hanby
  • Valerie SpeirsEmail author
Letter to the Editor

To the Editor,

Around two-thirds of all breast carcinomas respond to adjuvant endocrine therapy with the presence of ERα in tumour epithelial cells used to guide therapy. Other members of the steroid receptor superfamily have also been detected in breast cancer epithelial cells, notably PR, AR, whose presence and potential prognostic role in breast cancer is gaining momentum [1, 2], and there is ongoing interest in the potential role of ERβ in breast carcinogenesis [3]. However, scientists are now looking beyond the epithelial landscape with the recognition that interaction of tumour epithelial cells with its surrounding microenvironment, particularly the stroma plays a role in promoting tumour growth and progression. While recognising that the stroma is multicellular, much of this attention has focused on fibroblasts residing in tumour stroma, termed carcinoma-associated fibroblasts (CAFs) as there is growing appreciation that CAFs may provide a favourable environment to augment...


Breast Carcinogenesis Tumour Epithelial Cell Breast Cancer Epithelial Cell Steroid Hormone Receptor Expression Steroid Receptor Superfamily 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



MEB is a Leeds Undergraduate Research Enterprise scholar.


  1. 1.
    Hu R, Dawood S, Holmes MD, Collins LC, Schnitt SJ, Cole K, Marotti JD, Hankinson SE, Colditz GA, Tamimi RM (2011) Androgen receptor expression and breast cancer survival in postmenopausal women. Clin Cancer Res 17:1867–1874PubMedCentralPubMedCrossRefGoogle Scholar
  2. 2.
    Peter MB, Shaaban AM, Rajan SS, Maraqa L, Horgan K, Speirs V (2011) Investigating and critically appraising the expression and potential role of androgen receptor in breast carcinoma. Hormone Mol Biol Clin Invest 7:273–278CrossRefGoogle Scholar
  3. 3.
    Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM (2012) Estrogen receptor-beta and breast cancer: translating biology into clinical practice. Steroids 77:727–737PubMedCentralPubMedCrossRefGoogle Scholar
  4. 4.
    Tripathi M, Billet S, Bhowmick NA (2012) Understanding the role of stromal fibroblasts in cancer progression. Cell Adhes Migr 6:231–235CrossRefGoogle Scholar
  5. 5.
    Knower KC, Chand AL, Eriksson N, Takagi K, Miki Y, Sasano H, Visvader JE, Lindeman GJ, Funder JW, Fuller PJ, Simpson ER, Tilley WD, Leedman P, Graham JD, Muscat GE, Clarke CL, Clyne CD (2013) Distinct nuclear receptor expression in stroma adjacent to breast tumors. Breast Cancer Res Treat 142:211–223PubMedCrossRefGoogle Scholar
  6. 6.
    Qiu J, Kulkarni S, Chandrasekhar R, Rees M, Hyde K, Wilding G, Tan D, Khoury T (2010) Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones. Am J Clin Pathol 134:813–819PubMedCrossRefGoogle Scholar
  7. 7.
    Skliris GP, Carder PJ, Lansdown MRJ, Speirs V (2001) Immunohistochemical detection of ERβ in breast cancer: towards more detailed receptor profiling? Br J Cancer 84:1095–1098PubMedCentralPubMedCrossRefGoogle Scholar
  8. 8.
    Shaaban AM, Green AR, Karthik S, Alizadeh Y, Hughes TA, Harkins L, Ellis IO, Robertson JF, Paish EC, Saunders PTK, Groome NP, Speirs V (2008) Nuclear and cytoplasmic expression of ERβ1, -2 and -5 identifies distinct prognostic outcome for breast cancer patients. Clin Cancer Res 14:5228–5235PubMedCrossRefGoogle Scholar
  9. 9.
    Smith L, Coleman LJ, Cummings M, Satheesha S, Shaw SO, Speirs V, Hughes TA (2010) Expression of estrogen receptor β isoforms is regulated by transcriptional and post-transcriptional mechanisms. Biochem J 429:283–290PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Mary E. Booth
    • 1
    • 2
  • Andrew M. Hanby
    • 2
  • Valerie Speirs
    • 2
    Email author
  1. 1.School of MedicineUniversity of LeedsLeedsUK
  2. 2.Leeds Institute of Cancer & PathologyUniversity of LeedsLeedsUK

Personalised recommendations