Breast Cancer Research and Treatment

, Volume 142, Issue 3, pp 611–618 | Cite as

Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referral

  • Sarah L. Ingham
  • Matthew Sperrin
  • Andrew Baildam
  • Gary L. Ross
  • Richard Clayton
  • Fiona Lalloo
  • Iain Buchan
  • Anthony Howell
  • D. Gareth R. Evans


The aim of this study was to establish if risk-reducing surgery (RRS) increases survival among BRCA1/2 carriers without breast/ovarian cancer at the time of family referral. Female BRCA1/2 carriers were identified from the Manchester Genetic Medicine Database. Those patients alive and unaffected at the date of first family ascertainment were included in this study. Female first-degree relatives (FDRs) without predictive genetic testing who otherwise met eligibility criteria were also included. The effect of breast and ovarian RRS on survival was analysed. The survival experiences of RRS and non-RRS patients, stratified by BRCA status, were examined with Kaplan–Meier curves and contrasted using log-rank tests and Cox models. 691 female BRCA1/2 mutation carriers without breast or ovarian cancer at time of family ascertainment were identified; 346 BRCA1 and 345 BRCA2. 105 BRCA1 carriers and 122 BRCA2 carriers developed breast cancer during follow-up. The hazard of death was statistically significantly lower (P < 0.001) following RRS versus no RRS. 10-year survival for women having RRS was 98.9 % (92.4–99.8 %) among BRCA1 and 98.0 % (92.2–99.5 %) among BRCA2 carriers. This survival benefit with RRS remained significant after FDRs were added. Women who had any form of RRS had increased survival compared to those who did not have RRS; a further increase in survival was seen among women who had both types of surgery. However, formal evidence for a survival advantage from bilateral mastectomy alone requires further research.


Survival Surgery BRCA Breast cancer 



FL and DGE are supported by the Manchester Biomedical Research Centre, DGE, AH and AB by the Genesis Breast Cancer Prevention Appeal. AH is supported by Breakthrough Breast Cancer DGE is an NIHR Senior Investigator.

Conflict of interest

The authors declare no conflict of interest.

Ethical standards

We declare that the work carried out in this manuscript comply with the current laws of the United Kingdom.


This study is unfunded research.

Supplementary material

10549_2013_2765_MOESM1_ESM.doc (40 kb)
Supplementary material 1 (DOC 41 kb)
10549_2013_2765_MOESM2_ESM.eps (91 kb)
Supplementary material 2 (EPS 92 kb)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Sarah L. Ingham
    • 1
    • 2
  • Matthew Sperrin
    • 1
  • Andrew Baildam
    • 3
  • Gary L. Ross
    • 4
  • Richard Clayton
    • 5
  • Fiona Lalloo
    • 6
  • Iain Buchan
    • 1
  • Anthony Howell
    • 2
    • 7
  • D. Gareth R. Evans
    • 2
    • 6
    • 7
  1. 1.Centre for Health Informatics, Institute of Population HealthThe University of ManchesterManchesterUK
  2. 2.Genesis Breast Cancer Prevention CentreUniversity Hospital of South Manchester NHS TrustManchesterUK
  3. 3.Barts Breast CentreSt Bartholomew’s HospitalLondonUK
  4. 4.Department of Plastic SurgeryThe Christie NHS Foundation TrustManchesterUK
  5. 5.Gynaecological Oncology, Manchester Academic Health Science CentreCentral Manchester Foundation Trust, St. Mary’s HospitalManchesterUK
  6. 6.Genetic Medicine, Manchester Academic Health Science CentreCentral Manchester Foundation Trust, St. Mary’s HospitalManchesterUK
  7. 7.Manchester Breast Centre, Manchester Cancer Research CentreUniversity of ManchesterManchesterUK

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