Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells
- 564 Downloads
It is now well accepted that tumor cells actively communicate with the tumor microenvironment (e.g., adipocytes) leading to the progression of breast cancer and other malignancies. It is also known that adipose mesenchymal stem cells (MSCs) have the ability to differentiate into mature adipocytes and initiate cytokine signaling within the tumor microenvironment. Here, we examine the role of MSC-differentiated adipocytes on breast cancer cell migration, and test the effects of sulforaphane (SFN, a dietary chemoprevention agent) on adipocyte–breast cancer cell interaction. Our results demonstrate that SFN promotes MSC self-renewal and inhibits adipogenic differentiation. Subsequently, SFN treatment of adipocytes considerably hinders cytokine communication with breast cancer cells, thereby decreasing breast cancer cell migration and tumor formation.
KeywordsSulforaphane Mammary Adipogenesis Adipose Mesenchymal stem cells Breast cancer cells
This work was supported by ACS (Q.Z.), NIH/NCI R01 (Q.Z.), and NIH (P30DK072488, D.W.G). The authors thank Carlo Mercado for help.
Conflict of interest
The authors declare that they have no conflict of interest.
- 8.Iyengar P, Combs TP, Shah SJ, Gouon-Evans V, Pollard JW, Albanese C, Flanagan L, Tenniswood MP, Guha C, Lisanti MP et al (2009) Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene 22:6408–6423CrossRefGoogle Scholar
- 17.Bechara C, Chai H, Lin PH, Yao Q, Chen C (2007) Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med sci monit: Int Med J Exp Clin Res 13:RA87–RA90Google Scholar