Breast Cancer Research and Treatment

, Volume 141, Issue 1, pp 1–12

Paget’s disease of the nipple

  • Ana C. Sandoval-Leon
  • Katherine Drews-Elger
  • Carmen R. Gomez-Fernandez
  • Monica M. Yepes
  • Marc E. Lippman
Review

Abstract

Paget’s disease of the breast is a disorder of the nipple–areola complex that, while rare, is often associated with an underlying carcinoma. It is characterized by eczematoid changes of the nipple. Two theories have been proposed to explain the pathogenesis of Paget’s disease. The Epidermotropic, which is the most accepted theory, suggests that Paget’s cells originate from ductal cancer cells that had migrated from the underlying breast parenchyma. It is supported by the predominance of breast cancer markers found in Paget’s disease. This article provides an overview of Paget’s disease of the breast with special attention to immunohistochemistry and raises the question of new therapeutic approaches.

Keywords

Paget’s disease Breast cancer Her2 Immunohistochemistry 

Abbreviations

PD

Paget’s disease

EMPD

Extra-mammary Paget’s disease

NAC

Nipple–areolar complex

ER

Estrogen receptor

PR

Progesterone receptor

AR

Androgen receptor

CK

Cytokeratin

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Ana C. Sandoval-Leon
    • 1
  • Katherine Drews-Elger
    • 1
  • Carmen R. Gomez-Fernandez
    • 2
  • Monica M. Yepes
    • 3
  • Marc E. Lippman
    • 1
  1. 1.Department of Medicine, Division of Hematology/OncologyUniversity of Miami Miller School of MedicineMiamiUSA
  2. 2.Department of PathologyUniversity of Miami Miller School of MedicineMiamiUSA
  3. 3.Department of RadiologyUniversity of Miami Miller School of MedicineMiamiUSA

Personalised recommendations