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Breast Cancer Research and Treatment

, Volume 139, Issue 2, pp 329–339 | Cite as

The impact of cyclin D1 overexpression on the prognosis of ER-positive breast cancers: a meta-analysis

  • Xiao-Ling Xu
  • Shu-Zheng Chen
  • Wei Chen
  • Wei-Hui Zheng
  • Xiang-Hou Xia
  • Hong-Jian Yang
  • Bo Li
  • Wei-Min MaoEmail author
Preclinical study

Abstract

Cyclin D1 (CCND1), a key regulator of cell cycle progression, is overexpressed in many human cancers, including breast cancer. However, the impact of CCND1 overexpression in these cancers remains unclear and controversial. We conducted a systematic literature search in PubMed and EMBASE with the search terms “cyclin D1”, “CCND1”, “breast cancer”, “prognosis”, and potential studies for analysis were selected. Studies with survival data, including progression-free survival (PFS), overall survival (OS) or metastasis-free survival (MFS), were included in this meta-analysis. A total of 33 studies containing 8,537 cases were included. The combined hazard risk (HR) and its 95 % confidence interval (CI) of OS, PFS and MFS were 1.13 (95 % CI 0.87–1.47; P = 0.35), 1.25 (95 % CI 0.95–1.64; P = 0.12), and 1.04 (95 % CI 0.80–1.36; P = 0.76), respectively, for primary breast cancer patients with tumors exhibiting CCND1 overexpression. Interestingly, the impact of CCND1 expression on OS was a 1.67-fold (95 % CI 1.38–2.02; P = 0.00) increased risk for ER-positive breast cancer patients. However, CCND1 overexpression exhibited no association with the PFS or OS of patients who received epirubicin-based neoadjuvant chemotherapy, for which the P values were 0.63 and 0.47, respectively. In summary, CCND1 overexpression impacts the prognosis of ER-positive breast cancer patients, but not patients with unselected primary breast cancer or patients treated with neoadjuvant chemotherapy.

Keywords

Cyclin D1 CCND1 Breast cancer Estrogen receptor Prognosis 

Notes

Acknowledgments

The authors thank Jian-Guo Feng at Zhejiang Cancer Hospital (Zhejiang Cancer Research Institute) for data statistics assistance. This study was supported by Province important technology and science (Special feature of major province scientific and technological 2011), No. 2011C13039-1, 2011–2014, and the establishment and NSFC general program, No. 81172081, 2012.01-2015-12.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Xiao-Ling Xu
    • 1
  • Shu-Zheng Chen
    • 2
  • Wei Chen
    • 1
  • Wei-Hui Zheng
    • 3
  • Xiang-Hou Xia
    • 3
  • Hong-Jian Yang
    • 3
  • Bo Li
    • 1
  • Wei-Min Mao
    • 1
    Email author
  1. 1.Key Laboratory on Diagnosis and Treatment Technology on Thoracic CancerZhejiang Cancer Hospital (Zhejiang Cancer Research Institute)HangzhouChina
  2. 2.Department of Breast SurgeryLishui Centre HospitalLishuiChina
  3. 3.Department of Breast SurgeryZhejiang Cancer HospitalHangzhouChina

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