Breast Cancer Research and Treatment

, Volume 136, Issue 3, pp 899–906 | Cite as

Patients’ willingness to participate in a breast cancer biobank at screening mammogram

  • Christoph I. Lee
  • Lawrence W. Bassett
  • Mei Leng
  • Sally L. Maliski
  • Bryan B. Pezeshki
  • Colin J. Wells
  • Carol M. Mangione
  • Arash Naeim
Epidemiology

Abstract

To characterize patients’ willingness to donate a biospecimen for future research as part of a breast cancer-related biobank involving a general screening population. We performed a prospective cross-sectional study of 4,217 women aged 21–89 years presenting to our facilities for screening mammogram between December 2010 and October 2011. This HIPAA-compliant study was approved by our institutional review board. We collected data on patients’ interest in and actual donation of a biospecimen, motivators and barriers to donating, demographic information, and personal breast cancer risk factors. A multivariate logistic regression analysis was performed to identify patient-level characteristics associated with an increased likelihood to donate. Mean patient age was 57.8 years (SD 11.1 years). While 66.0 % (2,785/4,217) of patients were willing to donate blood or saliva during their visit, only 56.4 % (2,378/4,217) actually donated. Women with a college education (OR = 1.27, p = 0.003), older age (OR = 1.02, p < 0.001), previous breast biopsy (OR = 1.23, p = 0.012), family history of breast cancer (OR = 1.23, p = 0.004), or a comorbidity (OR = 1.22, p = 0.014) were more likely to donate. Asian-American women were significantly less likely to donate (OR = 0.74, p = 0.005). The major reason for donating was to help all future patients (42.3 %) and the major reason for declining donation was privacy concerns (22.3 %). A large proportion of women participating in a breast cancer screening registry are willing to donate blood or saliva to a biobank. Among minority participants, Asian-American women are less likely to donate and further qualitative research is required to identify novel active recruitment strategies to insure their involvement.

Keywords

Biospecimen Biobank Breast cancer Screening Patient willingness 

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Christoph I. Lee
    • 1
    • 2
  • Lawrence W. Bassett
    • 3
  • Mei Leng
    • 4
  • Sally L. Maliski
    • 5
    • 6
    • 7
  • Bryan B. Pezeshki
    • 6
  • Colin J. Wells
    • 3
  • Carol M. Mangione
    • 2
    • 4
  • Arash Naeim
    • 4
    • 6
  1. 1.Department of RadiologyUniversity of Washington School of MedicineSeattleUSA
  2. 2.Robert Wood Johnson Foundation Clinical Scholars Program at UCLALos AngelesUSA
  3. 3.Department of Radiological SciencesDavid Geffen School of Medicine at UCLALos AngelesUSA
  4. 4.Department of MedicineDavid Geffen School of Medicine at UCLALos AngelesUSA
  5. 5.UCLA School of NursingLos AngelesUSA
  6. 6.Jonsson Comprehensive Cancer CenterLos AngelesUSA
  7. 7.Department of Health ServicesFielding School of Public Health at UCLALos AngelesUSA

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