A bias in genotyping the miR-27a rs895819 and rs11671784 variants
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To the Editor,
Due to the oncogenetic function of miR-27a, SNPs affecting this gene are frequently investigated for an influence on cancer risk. Yang et al.  has reported the association between the minor [G] allele of rs895819 on miR-27a and a reduced familial breast cancer risk in German population by direct sequencing. One study in Chinese Han population also observed a tumor suppressive effect of the rs895819 [G] allele in gastric cancer using MALDI-TOF MassARRAY .
KeywordsTaqMan Probe German Population Familial Breast Cancer Tumor Suppressive Effect Nucleotide Distance
We thank Ludwig Heesen, Michelle Dick, Ying Wang and Anja Schwaeger for participating in genotyping. We are grateful to Bowang Chen for statistical analyses as well as to Sandrine Tchatchou for support. The German breast cancer samples were collected within a project funded by the Deutsche Krebshilfe (Grant Number: 107054). This study was supported by the Helmholtz society, the German Cancer Research Center (DKFZ), EU, LSHC-CT-2004-503465 and the Dietmar-Hopp Foundation.
Conflict of interest