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Breast Cancer Research and Treatment

, Volume 134, Issue 2, pp 859–866 | Cite as

The influence of mammographic density on breast tumor characteristics

  • Louise ErikssonEmail author
  • Kamila Czene
  • Lena Rosenberg
  • Keith Humphreys
  • Per Hall
Epidemiology

Abstract

Mammographic density (MD) is a well-established risk factor for breast cancer. Whether MD influences the tumor phenotype remains to be clarified. Previous studies are highly inconsistent and most lack important covariate information. This is a case-only study within a population-based case–control study. Cases were all postmenopausal women, aged 50–74 years, with incident breast cancer, diagnosed 1993–1995, and with no history of previous cancer (n = 2,720). 1,747 women with mammograms and information on tumor characteristics were included in analyses. MD was assessed using a computer-assisted thresholding technique. We used linear, logistic, and multinomial logistic regression, adjusting for possible confounders, to study density and tumor characteristics. PD was only statistically significantly associated with tumor size in our study (regression coefficient 0.031, p = 0.017). The effect of PD on tumor size was greater when mode of detection was excluded from the model (regression coefficient 0.043, p = 0.001). No other associations between PD and the tumor characteristics studied (lymph node metastasis, ER-status, PR-status, grade, and histopathological classification) were observed. In summary, PD was positively associated with tumor size in postmenopausal women. However, the relationship was at least partially confounded by mode of detection. Although there may be a true biological relationship between MD and more highly proliferative tumors, it also seems that part of this relationship is due to masking delaying diagnosis. In conclusion, PD does not seem to be differentially associated with tumor phenotype, except for tumor size, after taking mode of detection into consideration.

Keywords

Mammographic density Breast cancer Tumor characteristics Tumor size 

Abbreviation

BMI

Body mass index

CI

Confidence interval

ER

Estrogen receptor

HRT

Hormone replacement therapy

MD

Mammographic density

OR

Odds ratio

PD

Percentage density

PR

Progesterone receptor

Notes

Acknowledgments

This study was funded by Märit and Hans Rausing’s Initiative against Breast Cancer and the Swedish Research Council grant no: 521-2011-3187. KC was financed by the Swedish Cancer Society grant no: 5128-B07-01PAF. KH was supported by the Swedish Research Council (523-2006-972). The funding sources had no role in the study design, data collection, analysis, interpretation of data, writing of the manuscript, or in the decision to submit the manuscript for publication.

Ethical approval

Approval of the study was given by the ethical review board at the Karolinska Institutet (Stockholm, Sweden) and six other ethical review boards in the respective regions from which the subjects were based.

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Louise Eriksson
    • 1
    Email author
  • Kamila Czene
    • 1
  • Lena Rosenberg
    • 1
    • 2
  • Keith Humphreys
    • 1
  • Per Hall
    • 1
  1. 1.Institution of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  2. 2.Department of RadiologyDanderyds HospitalStockholmSweden

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