Breast Cancer Research and Treatment

, Volume 134, Issue 2, pp 815–822 | Cite as

The economic burden of metastatic breast cancer: a U.S. managed care perspective

  • Alberto J. Montero
  • Sara Eapen
  • Brian Gorin
  • Paulette Adler


This study was performed to quantify the economic burden and identify drivers of direct costs of mBC. In a retrospective study of a de-identified administrative claims database of privately insured patients, women between 18 and 64 years of age were included if they had at least one claim with a diagnosis of breast cancer and subsequently one or more claims with a diagnosis of secondary malignancy between January 1, 2003 and December 31, 2009. The study sample was further classified into the following subgroups: (1) Endocrine therapy, (2) HER-2 targeted therapy, (3) Concomitant HER-2 targeted and endocrine therapy, (4) Cytotoxic chemotherapy, and (5) No-systemic therapy. Costs for medical resource utilization were calculated on a per patient per month (PPPM) basis. A total of 7,698 mBC patients were identified from 2003 to 2009 with an average age at index of ~52 years, and average follow up of 2.2 years. The average total direct medical costs for 7,698 mBC patients were $9,788 PPPM. Outpatient costs accounted for the majority of overall PPPM costs. Examining the five different mBC therapeutic subgroups revealed that patients who received no-systemic therapy had the highest costs at $13,926 PPPM, while patients who received systemic endocrine therapy had the lowest costs at $5,303 PPPM. This study demonstrated that mBC is associated with substantial healthcare costs in a non-Medicare patient population. Assuming average PPPM costs of $9,788 and an average life expectancy of 2.2 years, the total average expenditure to treat mBC would be ~$250,000 per patient.


Metastatic breast cancer Healthcare costs Resource utilization Economic burden 


Conflict of interest

The authors (SE, BG) received funding from Veridex, LLC. AJM has no conflict of interests to declare and received no funding for his contributions to this project.


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Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  • Alberto J. Montero
    • 1
  • Sara Eapen
    • 2
  • Brian Gorin
    • 2
  • Paulette Adler
    • 3
  1. 1.Division of Hematology/Oncology, Sylvester Comprehensive Cancer CenterUniversity of MiamiMiamiUSA
  2. 2.Analysis Group, IncBostonUSA
  3. 3.Veridex, LLCRaritanUSA

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