Comment on the review by Joshi and Buehring
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To the Editor,
We read with interest and dismay the review by Joshi and Buehring (published on line) January 25, 2012 . These reviewers chose 4 of 25 publications that “convincingly” failed to confirm the presence of MMTV-LS viral sequences in patients with breast cancer. These four small studies [2–5] used primers and/or reaction conditions different from our reports. In contrast, 21 of 25 studies reported positive assays in at least 500 breast cancer patients from our studies in New York  and in patients from the Australian group  Tunisia , Mexico , Russia , China , Italy  and elsewhere in the United States . The reviewers also omitted one of our crucial articles: we have reported RNA sequences homologous to the MMTV-LS proviral DNA isolated from viral particles produced in cell culture . We previously had shown that normal tissue from the same breast, positive for MMTV-LS, was negative . We have shown fluorescent in situ hybridization of...
KeywordsBreast Cancer Human Breast Cancer Inflammatory Breast Cancer Mouse Mammary Tumor Virus Human Mammary Epithelial Cell
References for Rebuttal letter
- 1.Joshi D, Buehring GC (2012) Are viruses associated with human breast cancer? Scrutinizing the molecular evidence. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1921-4