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Breast Cancer Research and Treatment

, Volume 136, Issue 1, pp 303–307 | Cite as

Comment on the review by Joshi and Buehring

  • James F. HollandEmail author
  • Beatriz G.-T. Pogo
Letter to the Editor

To the Editor,

We read with interest and dismay the review by Joshi and Buehring (published on line) January 25, 2012 [1]. These reviewers chose 4 of 25 publications that “convincingly” failed to confirm the presence of MMTV-LS viral sequences in patients with breast cancer. These four small studies [2–5] used primers and/or reaction conditions different from our reports. In contrast, 21 of 25 studies reported positive assays in at least 500 breast cancer patients from our studies in New York [6] and in patients from the Australian group [7] Tunisia [8], Mexico [9], Russia [10], China [11], Italy [12] and elsewhere in the United States [13]. The reviewers also omitted one of our crucial articles: we have reported RNA sequences homologous to the MMTV-LS proviral DNA isolated from viral particles produced in cell culture [14]. We previously had shown that normal tissue from the same breast, positive for MMTV-LS, was negative [15]. We have shown fluorescent in situ hybridization of...

Keywords

Breast Cancer Human Breast Cancer Inflammatory Breast Cancer Mouse Mammary Tumor Virus Human Mammary Epithelial Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References for Rebuttal letter

  1. 1.
    Joshi D, Buehring GC (2012) Are viruses associated with human breast cancer? Scrutinizing the molecular evidence. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1921-4
  2. 2.
    Fukuoka H, Moriuch M, Yano H, Nagayasu T, Moriuchi H (2008) No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer. J Med Virol 80:1447–1451PubMedCrossRefGoogle Scholar
  3. 3.
    Park DJ, Souuthey MC, Giles GG, Hopeer JL (2011) No evidence of MMTV-like env sequences in specimens from the Australian Breast Cancer Family Study. Breast Cancer Res Treat 125:229–235PubMedCrossRefGoogle Scholar
  4. 4.
    Zangen R, Harden S, Cohen D, Parrella P, Sidransky D (2002) Mouse mammary tumor-like env gene as a molecular marker for breast cancer? Int J Cancer 102:304–307PubMedCrossRefGoogle Scholar
  5. 5.
    Bindra A, Muradrasoli S, Kisekka R, Kisseka R, Nordgren H, Warnberg F, Blomberg J (2007) Search for DNA of exogenous mouse mammary tumor virus-related virus in human breast cancer samples. J Gen Virol 88:1806–1809PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  1. 1.Mount Sinai School of MedicineNew YorkUSA

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