Breast Cancer Research and Treatment

, Volume 136, Issue 1, pp 303–307 | Cite as

Comment on the review by Joshi and Buehring

  • James F. HollandEmail author
  • Beatriz G.-T. Pogo
Letter to the Editor

To the Editor,

We read with interest and dismay the review by Joshi and Buehring (published on line) January 25, 2012 [1]. These reviewers chose 4 of 25 publications that “convincingly” failed to confirm the presence of MMTV-LS viral sequences in patients with breast cancer. These four small studies [2–5] used primers and/or reaction conditions different from our reports. In contrast, 21 of 25 studies reported positive assays in at least 500 breast cancer patients from our studies in New York [6] and in patients from the Australian group [7] Tunisia [8], Mexico [9], Russia [10], China [11], Italy [12] and elsewhere in the United States [13]. The reviewers also omitted one of our crucial articles: we have reported RNA sequences homologous to the MMTV-LS proviral DNA isolated from viral particles produced in cell culture [14]. We previously had shown that normal tissue from the same breast, positive for MMTV-LS, was negative [15]. We have shown fluorescent in situ hybridization of...


Breast Cancer Human Breast Cancer Inflammatory Breast Cancer Mouse Mammary Tumor Virus Human Mammary Epithelial Cell 
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References for Rebuttal letter

  1. 1.
    Joshi D, Buehring GC (2012) Are viruses associated with human breast cancer? Scrutinizing the molecular evidence. Breast Cancer Res Treat. doi: 10.1007/s10549-011-1921-4
  2. 2.
    Fukuoka H, Moriuch M, Yano H, Nagayasu T, Moriuchi H (2008) No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer. J Med Virol 80:1447–1451PubMedCrossRefGoogle Scholar
  3. 3.
    Park DJ, Souuthey MC, Giles GG, Hopeer JL (2011) No evidence of MMTV-like env sequences in specimens from the Australian Breast Cancer Family Study. Breast Cancer Res Treat 125:229–235PubMedCrossRefGoogle Scholar
  4. 4.
    Zangen R, Harden S, Cohen D, Parrella P, Sidransky D (2002) Mouse mammary tumor-like env gene as a molecular marker for breast cancer? Int J Cancer 102:304–307PubMedCrossRefGoogle Scholar
  5. 5.
    Bindra A, Muradrasoli S, Kisekka R, Kisseka R, Nordgren H, Warnberg F, Blomberg J (2007) Search for DNA of exogenous mouse mammary tumor virus-related virus in human breast cancer samples. J Gen Virol 88:1806–1809PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC. 2012

Authors and Affiliations

  1. 1.Mount Sinai School of MedicineNew YorkUSA

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