Breast Cancer Research and Treatment

, Volume 132, Issue 2, pp 631–639

Outcomes of a weight loss intervention among rural breast cancer survivors

  • Christie A. Befort
  • Jennifer R. Klemp
  • Heather L. Austin
  • Michael G. Perri
  • Kathryn H. Schmitz
  • Debra K. Sullivan
  • Carol J. Fabian
Clinical trial

Abstract

Obese breast cancer survivors have increased risk of recurrence and death compared to their normal weight counterparts. Rural women have significantly higher obesity rates, thus weight control intervention may be a key strategy for prevention of breast cancer recurrence in this population. This one-arm treatment study examined the impact of a group-based weight control intervention delivered through conference call technology to obese breast cancer survivors living in remote rural locations. The intervention included a reduced calorie diet incorporating prepackaged entrees and shakes, physical activity gradually increased to 225 min/week of moderate intensity exercise, and weekly group phone sessions. Outcomes included anthropomorphic, diet, physical activity, serum biomarker, and quality of life changes. Ninety-one percent of participants (31 of 34) attended >75% of intervention sessions and completed post-treatment data collection visits. At 6 months, significant changes were observed for weight (−12.5 ± 5.8 kg, 13.9% of baseline weight), waist circumference (−9.4 ± 6.3 cm), daily energy intake (−349 ± 550 kcal/day), fruits, and vegetables (+3.7 ± 4.3 servings/day), percent kcal from fat (−12.6 ± 8.6%), physical activity (+1235 ± 832 kcal/week; all P values <0.001), as well as significant reductions in fasting insulin (16.7% reduction, P = 0.006), and leptin (37.1% reduction, P < 0.001). Significant improvements were also seen for quality of life domains including mood, body image, and sexuality. In conclusion, the intervention produced >10% weight loss as well as significant improvements across multiple endpoints. The group phone-based treatment delivery approach may help disseminate effective weight control intervention to hard-to-reach breast cancer survivors.

Keywords

Breast cancer Survivors Rural Weight control Physical activity 

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Christie A. Befort
    • 1
  • Jennifer R. Klemp
    • 2
  • Heather L. Austin
    • 1
  • Michael G. Perri
    • 3
  • Kathryn H. Schmitz
    • 4
  • Debra K. Sullivan
    • 5
  • Carol J. Fabian
    • 2
  1. 1.Department of Preventive Medicine and Public HealthUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Medical Oncology, Breast Cancer Prevention and Survivorship CenterUniversity of Kansas Medical CenterKansas CityUSA
  3. 3.College of Public Health and Health Professions, University of FloridaGainesvilleUSA
  4. 4.Division of Clinical EpidemiologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  5. 5.Department of Dietetics and NutritionUniversity of Kansas Medical CenterKansas CityUSA

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