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Breast Cancer Research and Treatment

, Volume 133, Issue 3, pp 831–841 | Cite as

Locoregional recurrence after breast cancer surgery: a systematic review by receptor phenotype

  • Aoife J. Lowery
  • Malcolm R. Kell
  • Ronan W. Glynn
  • Michael J. Kerin
  • Karl J. Sweeney
Review

Abstract

Molecular subtyping confirms that breast cancer comprises at least four genetically distinct entities based on the expression of specific genes including estrogen receptor (ER), progesterone receptor (PR), and HER2/neu receptor. The quantitative influence of subtype on ipsilateral locoregional recurrence (LRR) is unknown. The aim of this study was to systematically appraise the influence of breast cancer subtype on LRR following breast conserving therapy (BCT) and mastectomy. A comprehensive search for studies examining outcomes after BCT and/or mastectomy according to breast cancer subtype was performed using Medline and cross-referencing available data. Reviews of each study were conducted and data extracted to perform meta-analysis. Primary outcome was LRR related to breast cancer subtype. A total of 12,592 breast cancer patients who underwent either BCT (n = 7,174) or mastectomy (n = 5,418) were identified from 15 studies. Patients with luminal subtype tumors (ER/PR +ve) had a lower risk of LRR than both triple-negative (RR 0.38; 95% CI 0.23–0.61); and HER2/neu-overexpressing (RR 0.34; 95% CI 0.26–0.45) tumors following BCT. Luminal tumors were also less likely to develop LRR than HER2/neu-overexpressing (OR 0.69; 95% CI 0.54–0.89) or triple-negative tumors (OR 0.61; 95% CI 0.46–0.79) after mastectomy. HER2/neu-overexpressing tumors have increased risk of LRR compared to triple-negative tumors (RR 1.44; 95% CI 1.06–1.95) following BCT but there was no difference in LRR between HER2/neu-overexpressing and triple-negative tumors following mastectomy (RR 0.91; 95% CI 0.68–1.22). Luminal tumors exhibit the lowest rates of LRR. Patients with triple-negative and HER2/neu-overexpressing breast tumors are at increased risk of developing LRR following BCT or mastectomy. Breast cancer subtype should be taken into account when considering local control and identifies those at increased risk of LRR, who may benefit from more aggressive local treatment.

Keywords

Breast cancer subtype Receptor phenotype Locoregional recurrence Breast conserving therapy 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10549_2011_1891_MOESM1_ESM.doc (54 kb)
Supplementary material 1 (DOC 54 kb)

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Aoife J. Lowery
    • 1
  • Malcolm R. Kell
    • 2
  • Ronan W. Glynn
    • 1
  • Michael J. Kerin
    • 1
  • Karl J. Sweeney
    • 1
    • 3
  1. 1.Surgery, School of MedicineNational University of IrelandGalwayIreland
  2. 2.Department of Surgery and Eccles Breast Screening UnitMater Misericordiae University HospitalDublinIreland
  3. 3.BreastCheck, Western UnitGalwayIreland

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