Breast Cancer Research and Treatment

, Volume 131, Issue 3, pp 1049–1059 | Cite as

High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

  • Aglaya G. Iyevleva
  • Ekatherina Sh. Kuligina
  • Nathalia V. Mitiushkina
  • Alexandr V. Togo
  • Yoshio Miki
  • Evgeny N. Imyanitov
Brief Report

Abstract

We analyzed the expression of several microRNAs (miRs) implicated in breast cancer (BC) pathogenesis (miR-21, miR-10b, miR17-5p, mir-31, miR-155, miR-200c, miR-18a, miR-205, and miR-27a) in 80 breast carcinomas obtained from patients with bilateral BC (biBC) and 40 cases of unilateral BC (uBC). Unexpectedly, three miRs (miR-21, miR-10b and miR-31) demonstrated significantly higher level of expression in biBC vs. uBC (P = 0.0001, 0.00004 and 0.0002, respectively). Increased contents of miR-21, miR-10b and miR-31 were observed in all categories of biBC tumors, i.e., in synchronous biBC as well as in first and second tumors from metachronous biBC cases. Synchronous biBC showed more similarity of miR expression profiles within pairs that the metachronous doublets (P = 0.004). This study suggests that bilateral breast tumors have somewhat distinct pattern of molecular events as compared to the unilateral disease.

Keywords

microRNA Bilateral breast cancer Breast cancer predisposition 

Notes

Acknowledgments

This study has been supported by the Russian Federation for Basic Research (grants 10-04-92110, 10-04-00260, 11-04-00227 and 11-04-01643), the Japanese Society for the Promotion of Science (JSPS) (project 10037711), the Federal Agency for Science and Innovations (contract 02.740.11.0780), the Commission of the European Communities (grant PITN-GA-2009-238132), and the Government of Moscow (grant 15/11).

Conflict of interest

None.

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Aglaya G. Iyevleva
    • 1
    • 2
  • Ekatherina Sh. Kuligina
    • 1
  • Nathalia V. Mitiushkina
    • 1
  • Alexandr V. Togo
    • 1
  • Yoshio Miki
    • 3
  • Evgeny N. Imyanitov
    • 1
    • 2
    • 4
  1. 1.Laboratory of Molecular OncologyN. N. Petrov Institute of OncologySt.-PetersburgRussia
  2. 2.Department of Medical GeneticsSt.-Petersburg Pediatric Medical AcademySt.-PetersburgRussia
  3. 3.Department of Genetic DiagnosisCancer Institute, Japanese Foundation for Cancer ResearchTokyoJapan
  4. 4.Department of OncologySt.-Petersburg Medical Academy for Postgraduate StudiesSt.-PetersburgRussia

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