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What can we learn from the age- and race/ethnicity- specific rates of inflammatory breast carcinoma?

  • Dora Il’yasovaEmail author
  • Sharareh Siamakpour-Reihani
  • Igor Akushevich
  • Lucy Akushevich
  • Neil Spector
  • Joellen Schildkraut
Brief Report

Abstract

Inflammatory Breast Carcinoma (IBC), the most aggressive type of breast tumor with unique clinicopathological presentation, is hypothesized to have distinct etiology with a socioeconomic status (SES) component. Using the Surveillance, Epidemiology and End Results (SEER) Program data for 2004–2007, we compare incidence rates of IBC to non-inflammatory locally advanced breast cancer (LABC) among racial/ethnic groups with different SES. The analysis includes women 20–84 years of age. To examine evidence for the distinct etiology of IBC, we analyzed age-distribution patterns of IBC and non-inflammatory LABC, using a mathematical carcinogenesis model. Based on the Collaborative Staging Extension codes, 2,942 incident IBC cases (codes 71 and 73) and 5,721 non-inflammatory LABC cases (codes 40–62) were identified during the four-year study period. Age-adjusted rates of IBC among non-Hispanic White and Hispanic women were similar (2.5/100,000 in both groups). Similar rates were also found in non-inflammatory LABC in these two groups (4.8/100,000 and 4.2/100,000, respectively). In African-American women, the IBC (3.91/100,000) and non-inflammatory LABC (8.47/100,000) rates were greater compared with other ethnic/racial sub-groups. However, the ratio of rates of IBC/non-inflammatory LABC was similar among all the racial/ethnic groups, suggesting that African-American women are susceptible to aggressive breast tumors in general but not specifically to IBC. The mathematical model successfully predicted the observed age-specific rates of both examined breast tumors and revealed distinct patterns. IBC rates increased until age 65 and then slightly decreased, whereas non-inflammatory LABC rates steadily increased throughout the entire age interval. The number of critical transition carcinogenesis stages (m-stages) predicted by the model were 6.3 and 8.5 for IBC and non-inflammatory LABC, respectively, supporting different etiologies of these breast tumors.

Keywords

Epidemiology Inflammatory breast cancer Etiology 

Abbreviations

CI

Confidence interval

CS extension

Collaborative staging extension

GDP

Gross domestic product

IBC

Inflammatory breast cancer

LABC

Locally advanced breast cancer

NAACCR

North American Association of Central Cancer Registries

SEER Program

Surveillance, Epidemiology and End Results Program

SES

Socioeconomic status

Notes

Conflict of interest

We have no conflicts of interest to report and have obtained written permission from all acknowledged in the manuscript.

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Dora Il’yasova
    • 1
    Email author
  • Sharareh Siamakpour-Reihani
    • 2
  • Igor Akushevich
    • 3
  • Lucy Akushevich
    • 2
  • Neil Spector
    • 4
  • Joellen Schildkraut
    • 2
  1. 1.Duke Cancer InstituteDurhamUSA
  2. 2.Duke Cancer InstituteDurhamUSA
  3. 3.Duke University Population Research InstituteDurhamUSA
  4. 4.Duke Cancer InstituteDurhamUSA

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