Breast Cancer Research and Treatment

, Volume 129, Issue 2, pp 309–317

Pregnancy after breast cancer: if you wish, ma’am

  • Olivia Pagani
  • Ann Partridge
  • Larissa Korde
  • Sunil Badve
  • John Bartlett
  • Kathy Albain
  • Richard Gelber
  • Aron Goldhirsch
Review

Abstract

A growing number of young breast cancer survivors consider reproductive health issues, including subsequent fertility and pregnancy, of great importance, but many questions regarding safety remain unanswered. We conducted a comprehensive literature search and review of published articles, control-matched, population-based, and co-operative group reports that addressed various aspects of pregnancy after breast cancer (patients’ expectations, fertility damage, assessment and preservation, maternal and fetal outcome, breast feeding). Overall, available data support pregnancy and breast feeding after breast cancer as safe and feasible for women at low risk of recurrence. This retrospective and population-based evidence is, however, frequently incomplete; usually not representative of the entire population, it can be biased by patients’ related effects or underpowered and is often not controlled for biological factors and risk determinants in the statistical model used. Before making any definitive assumption on this delicate and fundamental aspect of a woman’s life after breast cancer, we should demonstrate without any reasonable doubt that the scattered information available today is scientifically sound. The Breast International Group and North American Breast Cancer Group are planning a global prospective study in young women with endocrine responsive, early breast cancer who desire pregnancy, to assess both patients’ and pregnancy outcomes. The trial will include an observational phase investigating the feasibility and impact of a temporary treatment interruption to allow conception and an experimental phase investigating the optimal duration of the subsequent endocrine treatment after delivery or the last failed attempt to get pregnant.

Keywords

Breast cancer Pregnancy Fertility Breast feeding 

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Copyright information

© Springer Science+Business Media, LLC. 2011

Authors and Affiliations

  • Olivia Pagani
    • 1
  • Ann Partridge
    • 2
  • Larissa Korde
    • 3
  • Sunil Badve
    • 4
  • John Bartlett
    • 5
  • Kathy Albain
    • 6
  • Richard Gelber
    • 7
  • Aron Goldhirsch
    • 8
    • 9
  1. 1.Institute of Oncology of Southern Switzerland (IOSI) and International Breast Cancer Study Group (IBCSG)ViganelloSwitzerland
  2. 2.Dana-Farber Cancer InstituteBostonUSA
  3. 3.Division of Medical OncologyUniversity of WashingtonSeattleUSA
  4. 4.Pathology and Lab MedicineIndiana UniversityIndianapolisUSA
  5. 5.Endocrine Cancer Group, Edinburgh Cancer Research CentreEdinburghUK
  6. 6.Chicago Stritch School of MedicineLoyola UniversityMaywoodUSA
  7. 7.IBCSG Statistical Center, Dana-Farber Cancer Institute, Frontier Science and Technology Research Foundation, Harvard School of Public Health and Harvard Medical SchoolBostonUSA
  8. 8.Swiss Center for Breast HealthLuganoSwitzerland
  9. 9.European Institute of OncologyMilanItaly

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