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Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons

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Abstract

Intraoperative radiotherapy with electrons (ELIOT) after conservative surgery for breast carcinoma was introduced at the IEO in 1999 as a research programme. The results on 1,822 patients treated from January 2000 to December 2008 are reported. Women with unicentric primary breast carcinoma of less than 2.5 cm in the largest diameter were assessed by imaging. All patients were treated with breast-conserving surgery (quadrantectomy). ELIOT was delivered by two mobile linear accelerators immediately after breast resection with a single dose of 21 Gy. Local side effects of ELIOT were mainly liponecrosis (4.2%) and fibrosis (1.8%). After a mean follow-up of 36.1 months, 42 women (2.3%) developed a local recurrence, 24 (1.3%) a new primary ipsilateral carcinomas and 26 (1.4%) distant metastases as first event. Forty-six women died (2.5%), 28 for breast carcinoma and 18 for other causes. Five- and ten-year survivals were, respectively, 97.4 and 89.7%. ELIOT appears a promising feature in early breast cancer treated with breast conserving surgery, reducing the exposure of normal tissues to radiations and shortening the radiation course from 6 weeks to one single session.

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Acknowledgments

We thank the American-Italian Cancer Foundation, New York, Jacqueline Seroussi Foundation, Tel Aviv for financial support, William Russell-Edu for help with the English revision, and Maria Grazia Villardita for her constant help in the preparation of the manuscript.

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Authors and Affiliations

  1. European Institute of Oncology, Via Ripamonti 435, 20141, Milan, Italy

    Umberto Veronesi

  2. Division of Radiotherapy, European Institute of Oncology, Milan, Italy

    Roberto Orecchia, Maria Cristina Leonardi & Roberta Lazzari

  3. University of Milan School of Medicine, Milan, Italy

    Roberto Orecchia, Alberto Luini, Stefano Zurrida, Paolo Veronesi & Claudia Sangalli

  4. Division of Senology, European Institute of Oncology, Milan, Italy

    Alberto Luini, Viviana Galimberti, Stefano Zurrida, Mattia Intra, Paolo Veronesi, Paolo Arnone & Pietro Caldarella

  5. Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy

    Mario Ciocca

  6. Division of Epidemiology and Biostatistics, European Institute of Oncology, Milan, Italy

    Nicole Rotmensz & Patrick Maisonneuve

  7. Division of Anaesthesiology, European Institute of Oncology, Milan, Italy

    Daniele Sances

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  1. Umberto Veronesi
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Correspondence to Umberto Veronesi.

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Veronesi, U., Orecchia, R., Luini, A. et al. Intraoperative radiotherapy during breast conserving surgery: a study on 1,822 cases treated with electrons. Breast Cancer Res Treat 124, 141–151 (2010). https://doi.org/10.1007/s10549-010-1115-5

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  • DOI: https://doi.org/10.1007/s10549-010-1115-5

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