Breast Cancer Research and Treatment

, Volume 126, Issue 1, pp 177–183 | Cite as

Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects

  • Min-Bin Chen
  • Xiao-Yang Wu
  • Wei Shen
  • Mu-Xin Wei
  • Chen Li
  • Bin Cai
  • Guo-Qing Tao
  • Pei-Hua Lu


Trinucleotide repeat containing 9 (TNRC9) is a gene located at chromosome 16q12. Although of an uncertain function, it is a newly described risk factor for breast cancer. It contains a putative high-mobility group box motif, suggesting its possible role as transcription factor; it has been implicated in breast cancer metastasis. Published studies on the association between TNRC9 polymorphisms and breast cancer risk remain inconclusive, and a meta-analysis is required to verify the association. This pioneering research performed a meta-analysis of eight studies comprising a total of 25,828 cases and 36,177 controls. Significantly elevated breast cancer risk was associated with TNRC9 rs3803662 polymorphism when all studies were pooled in the meta-analysis (T vs. C allele contrast model: OR 1.18, 95% CI 1.09–1.28; TT vs. CC homozygote codominant model: OR 1.26, 95% CI 1.02–1.55; TT vs. CC+CT recessive model: OR 1.23, 95% CI 1.06–1.42). For TNRC9 rs12443621 polymorphism, no significant association was detected in all genetic models. For TNRC9 rs12443621 polymorphism, meanwhile, no significant association was observed in all comparison models. Conclusively, this meta-analysis suggests that TNRC9 rs3803662 polymorphism was significantly correlated with breast cancer risk and the variant T allele of TNRC9 rs3803662 polymorphism is a low-penetrant risk factor for developing breast cancer. There is no significant association between TNRC9 rs12443621 and rs8051542 polymorphisms and risk of breast cancer in current literature.


Trinucleotide repeat containing 9 (TNRC9) Breast cancer Genetic polymorphisms Risk 



The authors are fully responsible for all content and editorial decisions, and they have not received any financial support or other form of remuneration related to the development of this article.


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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Min-Bin Chen
    • 1
  • Xiao-Yang Wu
    • 1
  • Wei Shen
    • 2
  • Mu-Xin Wei
    • 3
  • Chen Li
    • 4
  • Bin Cai
    • 2
  • Guo-Qing Tao
    • 2
  • Pei-Hua Lu
    • 2
  1. 1.Department of OncologyKunshan People’s Hospital Affiliated To Jiangsu UniversityKunshanChina
  2. 2.Department of General SurgeryWuxi People’s Hospital of Nanjing Medical UniversityWuxiChina
  3. 3.Department of Traditional Chinese MedicineFirst Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  4. 4.Department of GastroenterologyXuzhou Chinese Medicine Hospital Affiliated To Nanjing University of Chinese MedicineXuzhouChina

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