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Breast Cancer Research and Treatment

, Volume 124, Issue 1, pp 133–140 | Cite as

Effect of neoadjuvant anthracycline–taxane-based chemotherapy in different biological breast cancer phenotypes: overall results from the GeparTrio study

  • Jens Huober
  • Gunter von Minckwitz
  • Carsten Denkert
  • Hans Tesch
  • Erich Weiss
  • Dirk Michael Zahm
  • Antje Belau
  • Fariba Khandan
  • Maik Hauschild
  • Christoph Thomssen
  • Bernhard Högel
  • Silvia Darb-Esfahani
  • Keyur Mehta
  • Sibylle LoiblEmail author
Clinical trial

Abstract

In order to explore the effect of neoadjuvant chemotherapy (NACT) on clinical mid-course and pathological complete response (pCR) at surgery in different biological breast cancer subtypes. The GeparTrio study included 2,072 patients with operable or locally advanced breast cancer. After two cycles with docetaxel, doxorubicin and cyclophosphamide (TAC) patients were randomized according to their clinical response. Clinical and biological factors were assessed for predicting clinically mid-course response and pCR at surgery. The overall pCR rate, defined as no invasive residuals in breast and axilla, was 20.5%. The highest pCR rate of 57% was observed in patients below 40 years of age with triple negative or grade 3 tumors. Independent factors for mid-course response and pCR were: young age, non-T4 tumors, high grade, and hormone receptor status, the strongest single predictive factor. Within the biological subtypes, grading was an independent factor to predict pCR for luminal tumors, clinical tumor stage for the HER2 like tumors and age for the triple negative ones. Grading gave independent information for mid-course response within the triple negative group. No factor predicted mid-course response within the other groups. Grading and age can identify subgroups within the luminal and triple negative patients who have an increased benefit from NACT.

Keywords

Neoadjuvant chemotherapy Breast cancer Predictive factors Lobular histology Age 

Supplementary material

10549_2010_1103_MOESM1_ESM.docx (23 kb)
Supplementary material 1 (DOCX 22 kb)

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Jens Huober
    • 1
    • 2
  • Gunter von Minckwitz
    • 3
  • Carsten Denkert
    • 4
  • Hans Tesch
    • 5
  • Erich Weiss
    • 6
  • Dirk Michael Zahm
    • 7
  • Antje Belau
    • 8
  • Fariba Khandan
    • 9
  • Maik Hauschild
    • 10
  • Christoph Thomssen
    • 11
  • Bernhard Högel
    • 12
  • Silvia Darb-Esfahani
    • 4
  • Keyur Mehta
    • 3
  • Sibylle Loibl
    • 3
    Email author
  1. 1.Brustzentrum Kantonsspital St. GallenSt. GallenSwitzerland
  2. 2.Department of GynaecologyUniversity TübingenTübingenGermany
  3. 3.German Breast GroupNeu-IsenburgGermany
  4. 4.Charité, Institute of Pathology, Translational Tumorpathology UnitBerlinGermany
  5. 5.Onkologische Gemeinschaftspraxis am Bethanien KrankenhausFrankfurt am MainGermany
  6. 6.Hospital Sindelfingen-BöblingenBöblingenGermany
  7. 7.SRH WaldklinikenGeraGermany
  8. 8.Department of GynaecologyUniversity GreifswaldGreifswaldGermany
  9. 9.St. Markus HospitalFrankfurt am MainGermany
  10. 10.Hospital RheinfeldenRheinfeldenGermany
  11. 11.Department of GynaecologyMartin Luther UniversityHalleGermany
  12. 12.Frauenklinik vom Roten KreuzMünchenGermany

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