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Breast Cancer Research and Treatment

, Volume 125, Issue 2, pp 489–493 | Cite as

VEGF 936C>T polymorphism and breast cancer risk: evidence from 5,729 cases and 5,868 controls

  • Dongying Gu
  • Meilin Wang
Epidemiology

Abstract

Vascular endothelial growth factor (VEGF) is one of the most potent endothelial cell mitogens and plays an important role in angiogenesis. Many published studies have evaluated the association between the VEGF 936C>T polymorphism and breast cancer risk. However, the published findings are inconsistent. In order to derive a more precise estimation of the association, a meta-analysis was performed in this study. A total of eight studies including 5,729 breast cancer cases and 5,868 controls were identified. Overall, no significant associations between the VEGF 936C>T polymorphism and breast cancer risk were found for TT versus CC (OR 0.93, 95% CI 0.73–1.19), CT versus CC (OR 0.91, 95% CI 0.77–1.09), TT/CT versus CC (OR 0.92, 95% CI 0.78–1.08), and TT versus CT/CC (OR 0.96, 95% CI 0.75–1.21). In the subgroup analysis by ethnicity, source of controls, and menopausal status, there was still no significant association detected in any of the genetic models. In summary, our results suggest that the VEGF 936C>T polymorphism may not contribute to breast cancer susceptibility.

Keywords

VEGF Breast cancer Meta-analysis Molecular epidemiology 

Notes

Acknowledgments

We thank Helena Chang (University of Wisconsin School of Medicine and Public Health) for scientific editing.

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  1. 1.Department of Molecular and Genetic Toxicology, School of Public HealthNanjing Medical UniversityNanjingPeople’s Republic of China
  2. 2.Department of Oncology, The Affiliated Nanjing First HospitalNanjing Medical UniversityNanjingPeople’s Republic of China

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