Breast Cancer Research and Treatment

, Volume 124, Issue 3, pp 827–834

Plasma tea polyphenol levels and subsequent risk of breast cancer among Japanese women: a nested case–control study

  • Motoki Iwasaki
  • Manami Inoue
  • Shizuka Sasazuki
  • Tsutomu Miura
  • Norie Sawada
  • Taiki Yamaji
  • Taichi Shimazu
  • Walter C. Willett
  • Shoichiro Tsugane
Epidemiology
  • 319 Downloads

Abstract

Although many in vitro and animal studies have suggested a protective effect of green tea against breast cancer, findings from epidemiological studies have been inconsistent. No study has used prediagnostic biomarkers of tea polyphenols, which might play a protective role. A total of 24,226 women aged 40 to 69 years in the Japan Public Health Center-based Prospective Study who responded to the baseline questionnaire and provided blood in 1990–1995 were followed to December 2002. During a mean 10.6 years of follow-up, 144 newly diagnosed breast cancers were identified. Two matched controls for each case were selected from the cohort. Plasma levels of (-)-epigallocatechin (EGC), (-)-epicatechin (EC), (-)-epigallocatechin-3-gallate (EGCG), and (-)-epicatechin-3-gallate (ECG) were measured, and the odds ratio (OR) of breast cancer according to plasma level was estimated using a conditional logistic regression model. We found no statistically significant association between plasma tea polyphenol levels and breast cancer risk. Adjusted ORs for the highest versus lowest group were 0.90 (95% CI 0.42–1.96; P for trend = 0.98) for EGC, 0.95 (95% CI 0.43–2.08; P for trend = 0.86) for EC, 1.21 (95% CI 0.52–2.80; P for trend = 0.53) for EGCG, and 1.75 (95% CI 0.81–3.78; P for trend = 0.15) for ECG. Stratified analyses according to baseline menopausal status showed no remarkable difference between two strata. This nested case–control study found no overall association between plasma tea polyphenols and the risk of breast cancer in Japan.

Keywords

Breast cancer Plasma tea polyphenol (-)-Epigallocatechin-3-gallate Nested case–control study 

Abbreviations

BMI

Body mass index

CI

Confidence interval

EC

(-)-Epicatechin

ECG

(-)-Epicatechin-3-gallate

EGC

(-)-Epigallocatechin

EGCG

(-)-Epigallocatechin-3-gallate

FFQ

Food frequency questionnaire

JPHC Study

Japan Public Health Center-based Prospective Study

OR

Odds ratio

PHC

Public health centers

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Motoki Iwasaki
    • 1
  • Manami Inoue
    • 1
  • Shizuka Sasazuki
    • 1
  • Tsutomu Miura
    • 1
    • 2
  • Norie Sawada
    • 1
  • Taiki Yamaji
    • 1
  • Taichi Shimazu
    • 1
  • Walter C. Willett
    • 3
    • 4
  • Shoichiro Tsugane
    • 1
  1. 1.Epidemiology and Prevention DivisionResearch Center for Cancer Prevention and Screening, National Cancer CenterTokyoJapan
  2. 2.Department of Health and Nutrition, Faculty of Human LifeJin-ai UniversityEchizenJapan
  3. 3.Departments of Nutrition and EpidemiologyHarvard School of Public HealthBostonUSA
  4. 4.Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital Harvard Medical SchoolBostonUSA

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