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Breast Cancer Research and Treatment

, Volume 124, Issue 3, pp 821–825 | Cite as

Three polymorphisms in interleukin-1β gene and risk for breast cancer: a meta-analysis

  • Xiaoan Liu
  • Zhanwei Wang
  • Jinhua Yu
  • Gang Lei
  • Shui Wang
Epidemiology

Abstract

Interleukin-1β (IL-1β), which is involved in inflammatory and immunological responses, plays an important role in the development and progression of breast cancer. Three functional single nucleotide polymorphisms (SNPs) identified in IL-1β gene are thought to influence breast cancer risk. The results of the association between IL-1β polymorphisms and breast cancer remain inconsistent. Therefore, we conducted a meta-analysis of eight case–control studies with rs1143627 (T > C), rs16944 (C > T), and rs1143634 (C > T). We found that the variant CC genotype of rs1143627 was associated with a significantly increased breast cancer risk (CC vs. TT: OR = 1.37, 95% CI = 1.10–1.70, P = 0.22 for heterogeneity; the recessive model CC vs. TT/TC: OR = 1.40, 95% CI = 1.17–1.67, P = 0.49 for heterogeneity). For rs16944 (C > T) and rs1143634 (C > T), no significant associations were found in all genetic models. In conclusion, the present meta-analysis suggests that rs1143627 is associated with breast cancer risk.

Keywords

Interleukin-1β Polymorphism Breast cancer Meta-analysis 

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Xiaoan Liu
    • 1
  • Zhanwei Wang
    • 2
  • Jinhua Yu
    • 3
  • Gang Lei
    • 3
  • Shui Wang
    • 1
  1. 1.Department of Breast SurgeryThe First Affiliated Hospital of Nanjing Medical UniversityNanjingChina
  2. 2.Department of Epidemiology and BiostatisticsNanjing Medical UniversityNanjingChina
  3. 3.Dental Research Institute, School of StomatologyNanjing Medical UniversityNanjingChina

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