Breast Cancer Research and Treatment

, Volume 124, Issue 1, pp 229–235

XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects

  • Li-Xin Qiu
  • Lei Yao
  • Jian Zhang
  • Xiao-Dong Zhu
  • Xin-Min Zhao
  • Kai Xue
  • Chen Mao
  • Bo Chen
  • Ping Zhan
  • Hui Yuan
  • Xi-Chun Hu
Epidemiology

Abstract

Published data on the association between Xeroderma Pigmentosum complementation group D (XPD) Lys751Gln polymorphism and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude ORs with 95% CIs were used to assess the strength of association between them. A total of 30 studies including 14,283 cases and 14,426 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with XPD 751Gln allele when all studies were pooled into the meta-analysis (Lys/Gln vs. Lys/Lys: OR = 1.13, 95% CI = 1.02–1.25; Gln/Gln vs. Lys/Lys: OR = 1.21, 95% CI = 1.06–1.38; dominant model: OR = 1.16, 95% CI = 1.05–1.29; and recessive model: OR = 1.14, 95% CI = 1.02–1.27). In the subgroup analysis by ethnicity, borderline significantly increased risks were found for Caucasians (Lys/Gln vs. Lys/Lys: OR = 1.09, 95% CI = 0.98–1.22; dominant model: OR = 1.10, 95% CI = 0.99–1.22) and significantly increased risks were found for Africans in dominant model (OR = 1.10, 95% CI = 1.04–1.15). When stratified by study design, statistically significantly elevated risk was found in population-based studies (Lys/Gln vs. Lys/Lys: OR = 1.10, 95% CI = 1.01–1.20; Gln/Gln vs. Lys/Lys: OR = 1.15, 95% CI = 1.01–1.31; dominant model: OR = 1.12, 95% CI = 1.03–1.23). In conclusion, this meta-analysis suggests that the XPD 751Gln allele is a low-penetrant risk factor for developing breast cancer.

Keywords

XPD Polymorphism Breast cancer Susceptibility Meta-analysis 

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Li-Xin Qiu
    • 1
    • 2
  • Lei Yao
    • 3
  • Jian Zhang
    • 1
    • 2
  • Xiao-Dong Zhu
    • 1
    • 2
  • Xin-Min Zhao
    • 1
    • 2
  • Kai Xue
    • 1
    • 2
  • Chen Mao
    • 4
  • Bo Chen
    • 5
  • Ping Zhan
    • 6
  • Hui Yuan
    • 7
  • Xi-Chun Hu
    • 1
    • 2
  1. 1.Department of Medical Oncology, Cancer HospitalFudan UniversityShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life SciencesFudan UniversityShanghaiChina
  4. 4.Department of Epidemiology, School of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhouChina
  5. 5.Department of Geriatrics, First Affiliated HospitalNanjing Medical UniversityNanjingChina
  6. 6.Department of Respiratory MedicineNanjing Chest HospitalNanjingChina
  7. 7.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityAnhuiChina

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