Breast Cancer Research and Treatment

, Volume 123, Issue 3, pp 863–868

TGF-β1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects

Epidemiology

DOI: 10.1007/s10549-010-0796-0

Cite this article as:
Huang, Y., Li, B., Qian, J. et al. Breast Cancer Res Treat (2010) 123: 863. doi:10.1007/s10549-010-0796-0

Abstract

Transforming growth factor β1 (TGF-β1) is a cytokine, playing an important role in controlling cell proliferation and differentiation involved in breast cancer. It was reported the 29T/C polymorphism in TGF-β1 has been implicated in breast cancer risk. However, studies on the association between this polymorphism and breast cancer remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 10,341 cases and 15,655 controls from fifty published case-control studies was performed. Our analysis suggested that 29T/C has no association with a trend of breast cancer risk when using both dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI) 0.96–1.07] and recessive models (OR = 0.98, 95% CI 0.89–1.08) to analyze the data. In ethnic subgroups analysis, 29T/C also did not appear to be risk factors for breast cancer. However, larger scale primary studies are required to further evaluate the interaction of TGF-β1 29T/C polymorphism and breast cancer risk in specific populations.

Keywords

TGF-β1 Breast cancer Polymorphism Meta-analysis 

Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  1. 1.State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life ScienceFudan UniversityShanghaiPeople’s Republic of China
  2. 2.Ben May Department for Cancer ResearchUniversity of ChicagoChicagoUSA

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