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Breast Cancer Research and Treatment

, Volume 123, Issue 3, pp 863–868 | Cite as

TGF-β1 29T/C polymorphism and breast cancer risk: a meta-analysis involving 25,996 subjects

  • Yongsheng Huang
  • Binghui Li
  • Ji Qian
  • Jingtian Xie
  • Long Yu
Epidemiology

Abstract

Transforming growth factor β1 (TGF-β1) is a cytokine, playing an important role in controlling cell proliferation and differentiation involved in breast cancer. It was reported the 29T/C polymorphism in TGF-β1 has been implicated in breast cancer risk. However, studies on the association between this polymorphism and breast cancer remain conflicting. To derive a more precise estimation of the relationship, a meta-analysis of 10,341 cases and 15,655 controls from fifty published case-control studies was performed. Our analysis suggested that 29T/C has no association with a trend of breast cancer risk when using both dominant [odds ratio (OR) = 1.01, 95% confidence intervals (CI) 0.96–1.07] and recessive models (OR = 0.98, 95% CI 0.89–1.08) to analyze the data. In ethnic subgroups analysis, 29T/C also did not appear to be risk factors for breast cancer. However, larger scale primary studies are required to further evaluate the interaction of TGF-β1 29T/C polymorphism and breast cancer risk in specific populations.

Keywords

TGF-β1 Breast cancer Polymorphism Meta-analysis 

Notes

Acknowledgements

This study was supported by National 973 Programs of China grant [2004CB518605 to L.Y.], the National 863 project of China [2006AA020501 to L.Y.],the National Key Sci-Tech Special Project of China [2008ZX10002-020], the Project of the Shanghai Municipal Science and Technology Commission [03dz14086], and the National Natural Science foundation of China [30024001, 30771188].

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  1. 1.State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life ScienceFudan UniversityShanghaiPeople’s Republic of China
  2. 2.Ben May Department for Cancer ResearchUniversity of ChicagoChicagoUSA

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