Breast Cancer Research and Treatment

, Volume 123, Issue 2, pp 507–524

Quality of life among women recently diagnosed with invasive breast cancer: the Pathways Study

  • Marilyn L. Kwan
  • Isaac Joshua Ergas
  • Carol P. Somkin
  • Charles P. QuesenberryJr.
  • Alfred I. Neugut
  • Dawn L. Hershman
  • Jeanne Mandelblatt
  • Michael P. Pelayo
  • Allegra W. Timperi
  • Sunita Q. Miles
  • Lawrence H. Kushi
Epidemiology

Abstract

Few studies have assessed quality of life (QOL) of women diagnosed with breast cancer within the first few weeks of their initial diagnosis. We describe QOL among 950 women recently diagnosed with invasive breast cancer. Starting in January 2006, we invited women aged ≥21 years who were diagnosed with first primary invasive breast cancer within Kaiser Permanente Northern California (KPNC) to enroll in the Pathways Study, a prospective study of breast cancer survivorship. QOL was measured using the Functional Assessment of Cancer Therapy-Breast Cancer (FACT-B), along with sociodemographic and social support information. Clinical characteristics were obtained from the KPNC cancer registry and electronic medical record. We used multivariable linear regression models to identify factors associated with QOL scores calculated from the FACT-B. The mean age ± SD of the sample was 59.6 years (±11.9 years), and the mean time ±SD from diagnosis until interview was 8.0 weeks (±3.2 weeks). Younger age at diagnosis was associated with lower scores in all QOL domains (P < 0.01), and later stage at diagnosis was associated with lower scores in all domains (P < 0.05) except for social well-being. Higher levels of social support were associated with higher QOL except for physical well-being (P < 0.05). These associations were stronger within 2 months of breast cancer diagnosis. Quality of life as influenced by a diagnosis of breast cancer is an important factor in cancer survivorship. Age, stage at diagnosis, and social support are key factors in this important variable.

Keywords

Quality of life FACT-B Social support Breast cancer Survival Age Stage 

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Copyright information

© Springer Science+Business Media, LLC. 2010

Authors and Affiliations

  • Marilyn L. Kwan
    • 1
  • Isaac Joshua Ergas
    • 1
  • Carol P. Somkin
    • 1
  • Charles P. QuesenberryJr.
    • 1
  • Alfred I. Neugut
    • 2
    • 3
  • Dawn L. Hershman
    • 2
    • 3
  • Jeanne Mandelblatt
    • 4
  • Michael P. Pelayo
    • 1
    • 5
  • Allegra W. Timperi
    • 1
  • Sunita Q. Miles
    • 1
  • Lawrence H. Kushi
    • 1
  1. 1.Division of ResearchKaiser PermanenteOaklandUSA
  2. 2.Department of EpidemiologyMailman School of Public Health, Columbia UniversityNew YorkUSA
  3. 3.Department of Medicine and Herbert Irving Comprehensive Cancer Center, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  4. 4.Department of Oncology and MedicineGeorgetown University Medical Center, Lombardi Comprehensive Cancer CenterWashingtonUSA
  5. 5.Helen Diller Family Comprehensive Cancer CenterUniversity of CaliforniaSan FranciscoUSA

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