Breast Cancer Research and Treatment

, Volume 121, Issue 3, pp 703–708 | Cite as

Glutathione S-transferase M1 polymorphism and breast cancer susceptibility: a meta-analysis involving 46,281 subjects

  • Li-Xin Qiu
  • Hui Yuan
  • Ke-Da Yu
  • Chen Mao
  • Bo Chen
  • Ping Zhan
  • Kai Xue
  • Jian Zhang
  • Xi-Chun Hu


Published data on the association between present/null polymorphism of glutathione S-transferase M1 (GSTM1) and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Medline, PubMed, Embase, and Web of Science were searched. Crude ORs with 95% CIs were used to assess the strength of association between the GSTM1 present/null polymorphism and breast cancer risk. The pooled ORs were performed for null versus present genotype. A total of 59 studies including 20,993 cases and 25,288 controls were involved in this meta-analysis. Overall, significantly elevated breast cancer risk was associated with null genotype when all studies were pooled into the meta-analysis (OR = 1.10, 95% CI = 1.04–1.16). In the subgroup analysis by ethnicity, significantly increased risks were found for Caucasians (OR = 1.05, 95% CI = 1.00–1.10) and Asians (OR = 1.21, 95% CI = 1.08–1.35). When stratified by population-based studies or hospital-based studies, statistically significantly elevated risks were found among population-based studies (OR = 1.11, 95% CI = 1.03–1.20). In the subgroup analysis by menopausal status, statistically significantly increased risks were found among postmenopausal women (OR = 1.15, 95% CI = 1.04–1.28). In conclusion, this meta-analysis suggests that the GSTM1 null genotype is a low-penetrant risk factor for developing breast cancer.


GSTM1 Polymorphism Breast cancer Susceptibility Meta-analysis 


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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Li-Xin Qiu
    • 1
    • 2
  • Hui Yuan
    • 3
  • Ke-Da Yu
    • 2
    • 4
  • Chen Mao
    • 5
  • Bo Chen
    • 6
  • Ping Zhan
    • 7
  • Kai Xue
    • 1
    • 2
  • Jian Zhang
    • 1
    • 2
  • Xi-Chun Hu
    • 1
    • 2
  1. 1.Department of Medical OncologyCancer Hospital, Fudan UniversityShanghaiChina
  2. 2.Department of Oncology, Shanghai Medical CollegeFudan UniversityShanghaiChina
  3. 3.Department of Epidemiology and Biostatistics, School of Public HealthAnhui Medical UniversityAnhuiChina
  4. 4.Breast Cancer Institute, Department of Breast SurgeryCancer Hospital, Fudan UniversityShanghaiChina
  5. 5.Department of Epidemiology, School of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhouChina
  6. 6.Department of Geriatrics, First Affiliated HospitalNanjing Medical UniversityNanjingChina
  7. 7.Department of Respiratory MedicineNanjing Chest HospitalNanjingChina

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