Breast Cancer Research and Treatment

, Volume 121, Issue 2, pp 479–483 | Cite as

The association of metabolic syndrome with triple-negative breast cancer

  • B. Maiti
  • M. N. Kundranda
  • T. P. Spiro
  • H. A. Daw
Epidemiology

Abstract

Metabolic syndrome, a conglomerate of obesity, insulin resistance, dyslipidemia, and hypertension has been linked with an increased risk of breast cancer. We investigated the possible association of highly aggressive triple-negative breast cancer and the metabolic syndrome. Information on metabolic syndrome components and tumor characteristics were reviewed in a cohort of 176 patients (including 86 triple-negatives). Retrospective comparison was performed using Pearson Chi-square test or Student’s t test for data analysis. A statistically significant association of triple-negative breast cancer with the metabolic syndrome was observed. In accordance with the NCEP (National Cholesterol Education Program) definition, 58.1% of triple-negative patients had metabolic syndrome compared to only 36.7% of non-triple-negative patients (P = 0.004). Consistently, by the AACE (American Association of Clinical Endocrinologists) criteria, 52.3% of triple-negative patients had metabolic syndrome as compared to 34.4% of non-triple-negative patients (P = 0.017). Blood glucose, triglyceride, and HDL levels but not hypertension or BMI (body mass index) showed significant independent association with triple-negative breast cancer. Additionally, triple-negative tumors displayed a significantly higher histological grade and relative paucity of ductal carcinoma in situ (DCIS) when compared to the non-triple-negative tumors (P < 0.001). Our study suggests that metabolic syndrome is significantly more prevalent in triple-negative breast cancer patients as opposed to non-triple-negative patients. Furthermore, triple-negative breast cancer showed a significantly higher histological grade and a relative absence of DCIS. Whether the presence of metabolic syndrome preferentially increases the risk of developing triple-negative-breast cancer remains to be elucidated with future prospective studies.

Keywords

Breast cancer Triple-negative Metabolic syndrome Epidemiology 

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Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • B. Maiti
    • 1
  • M. N. Kundranda
    • 1
  • T. P. Spiro
    • 2
  • H. A. Daw
    • 2
  1. 1.Department of Internal MedicineFairview Hospital, a Cleveland Clinic HospitalClevelandUSA
  2. 2.Cleveland Clinic Cancer Center at Fairview HospitalClevelandUSA

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