Breast Cancer Research and Treatment

, Volume 121, Issue 3, pp 765–769

Two-stage case–control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk

  • Chuanzhong Ye
  • Alicia Beeghly-Fadiel
  • Wei Lu
  • Jirong Long
  • Xiao Ou Shu
  • Yu-Tang Gao
  • Wei Zheng
  • Qiuyin Cai
Brief Report

DOI: 10.1007/s10549-009-0569-9

Cite this article as:
Ye, C., Beeghly-Fadiel, A., Lu, W. et al. Breast Cancer Res Treat (2010) 121: 765. doi:10.1007/s10549-009-0569-9

Abstract

Aberrant DNA methylation of CpG islands is a common epigenetic alteration found in cancers. DNA methylation is typically mediated by DNA methyltransferases (DNMTs). Only two studies have evaluated DNMT-1 and/or DNMT-3B gene polymorphisms in relation to breast cancer risk, and results have been inconsistent. We comprehensively evaluated genetic variations in the DNMT-1 and DNMT-3B genes with breast cancer risk among the participants of the Shanghai Breast Cancer Study, a large-scale, two-stage, case–control study. Of the 25 SNPs in the DNMT-1 and DNMT-3B genes analyzed, only one (rs8101866) reached a normal significance level (P = 0.042). This association, however, was no longer statistically significant after adjustment for multiple comparisons. Our data suggest that there is no apparent association of common DNMT-1 and DNMT-3B polymorphisms with the risk of breast cancer among Chinese women.

Keywords

Breast cancer SNPs DNMT-1 DNMT-3B Risk 

Abbreviations

CI

Confidence interval

DNMT

DNA methyltransferase

htSNPs

Haplotype tagging SNPs

HWE

Hardy–Weinberg equilibrium

LD

Linkage disequilibrium

MAF

Minor allele frequency

QC

Quality control

SNP

Single nucleotide polymorphism

Copyright information

© Springer Science+Business Media, LLC. 2009

Authors and Affiliations

  • Chuanzhong Ye
    • 1
  • Alicia Beeghly-Fadiel
    • 1
  • Wei Lu
    • 2
  • Jirong Long
    • 1
  • Xiao Ou Shu
    • 1
  • Yu-Tang Gao
    • 3
  • Wei Zheng
    • 1
  • Qiuyin Cai
    • 1
  1. 1.Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer CenterVanderbilt University School of MedicineNashvilleUSA
  2. 2.Shanghai Center for Disease Control and PreventionShanghaiChina
  3. 3.Department of EpidemiologyShanghai Cancer InstituteShanghaiChina

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