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Acupuncture for treating hot flashes in breast cancer patients: a systematic review

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Abstract

The objective of this review was to assess the effectiveness of acupuncture as a treatment option for hot flashes in patients with breast cancer. We searched the literature using 14 databases from their inceptions to August 2008, without language restrictions. We included randomised clinical trials (RCTs) comparing real with sham acupuncture or another active treatment or no treatment. Their methodological quality was assessed using the modified Jadad score. Three RCTs compared the effects of manual acupuncture with sham acupuncture. One RCT showed favourable effects of acupuncture in reducing hot flash frequency, while other two RCTs failed to do so. The meta-analysis show significant effects of acupuncture compared with sham acupuncture (n = 189, weight mean difference, 3.09, 95% confidence intervals −0.04 to 6.23, P = 0.05) but marked heterogeneity was observed in this model (χ 2 = 8.32, P = 0.02, I 2 = 76%). One RCT compared the effects of electroacupuncture (EA) with hormone replacement therapy. Hormone therapy was more effective than EA. Another RCT compared acupuncture with venlafaxine and reported no significant intergroup difference. A further RCT compared acupuncture with applied relaxation and failed to show a significant intergroup difference. In conclusion, the evidence is not convincing to suggest acupuncture is an effective treatment of hot flash in patients with breast cancer. Further research is required to investigate whether there are specific effects of acupuncture for treating hot flash in patients with breast cancer.

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References

  1. Stearns V, Loprinzi CL (2003) New therapeutic approaches for hot flashes in women. J Support Oncol 1:11–21 discussion 14–15, 19–21

    PubMed  CAS  Google Scholar 

  2. Antoine C, Vandromme J, Fastrez M, Carly B, Liebens F, Rozenberg S (2008) A survey among breast cancer survivors: treatment of the climacteric after breast cancer. Climacteric 11:322–328. doi:10.1080/13697130802244422

    Article  PubMed  CAS  Google Scholar 

  3. Daley A, MacArthur C, McManus R et al (2006) Factors associated with the use of complementary medicine and non-pharmacological interventions in symptomatic menopausal women. Climacteric 9:336–346. doi:10.1080/13697130600864074

    Article  PubMed  CAS  Google Scholar 

  4. Kessel B, Kronenberg F (2004) The role of complementary and alternative medicine in management of menopausal symptoms. Endocrinol Metab Clin North Am 33:717–739. doi:10.1016/j.ecl.2004.07.004

    Article  PubMed  CAS  Google Scholar 

  5. Kronenberg F, Fugh-Berman A (2002) Complementary and alternative medicine for menopausal symptoms: a review of randomized, controlled trials. Ann Intern Med 137:805–813

    PubMed  Google Scholar 

  6. Newton KM, Buist DS, Keenan NL, Anderson LA, LaCroix AZ (2002) Use of alternative therapies for menopause symptoms: results of a population-based survey. Obstet Gynecol 100:18–25. doi:10.1016/S0029-7844(02)02005-7

    Article  PubMed  Google Scholar 

  7. Arai YC, Ushida T, Osuga T et al (2008) The effect of acupressure at the extra 1 point on subjective and autonomic responses to needle insertion. Anesth Analg 107:661–664

    Article  PubMed  Google Scholar 

  8. Backer M, Grossman P, Schneider J et al (2008) Acupuncture in migraine: investigation of autonomic effects. Clin J Pain 24:106–115

    Article  PubMed  Google Scholar 

  9. Uchida S, Hotta H (2008) Acupuncture affects regional blood flow in various organs. Evid Based Complement Altern Med 5:145–151. doi:10.1093/ecam/nem051

    Article  Google Scholar 

  10. Jadad AR, Moore RA, Carroll D et al (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12. doi:10.1016/0197-2456(95)00134-4

    Article  PubMed  CAS  Google Scholar 

  11. White AR, Ernst E (1999) A systematic review of randomized controlled trials of acupuncture for neck pain. Rheumatology 38:143–147. doi:10.1093/rheumatology/38.2.143

    Article  PubMed  CAS  Google Scholar 

  12. Follmann D, Elliott P, Suh I, Cutler J (1992) Variance imputation for overviews of clinical trials with continuous response. J Clin Epidemiol 45:769–773. doi:10.1016/0895-4356(92)90054-Q

    Article  PubMed  CAS  Google Scholar 

  13. Deng G, Vickers A, Yeung S, Cassileth B (2007) Randomized, controlled trial of acupuncture for the treatment of hot flashes in breast cancer patients. J Clin Oncol 25:5584–5590. doi:10.1200/JCO.2007.12.0774

    Article  PubMed  Google Scholar 

  14. Davies FM (2001) The effect of acupuncture treatment on the incidence and severity of hot flushes experienced by women following treatment for breast cancer: a comparison of traditional and minimal acupuncture. Eur J Cancer 37:S438–S438. doi:10.1016/S0959-8049(01)82079-7

    Article  Google Scholar 

  15. Hervik J, Mjåland O (2008) Acupuncture for the treatment of hot flashes in breast cancer patients, a randomized, controlled trial. Breast Cancer Res Treat. doi:10.1007/s10549-008-0210-3

  16. Frisk J, Carlhall S, Kallstrom AC, Lindh-Astrand L, Malmstrom A, Hammar M (2008) Long-term follow-up of acupuncture and hormone therapy on hot flushes in women with breast cancer: a prospective, randomized, controlled multicenter trial. Climacteric 11:166–174. doi:10.1080/13697130801958709

    Article  PubMed  CAS  Google Scholar 

  17. Walker EM, Rodriguez AI, Kohn B, Pegg J, Bell RM, Levine RA (2008) Acupuncture for the treatment of vasomotor symptoms in breast cancer patients receiving hormone suppression treatment. Int J Radiat Oncol Biol Phys 72:S103–S103. doi:10.1016/j.ijrobp.2008.06.1000

    Google Scholar 

  18. Nedstrand E, Wijma K, Wyon Y, Hammar M (2005) Vasomotor symptoms decrease in women with breast cancer randomized to treatment with applied relaxation or electro-acupuncture: a preliminary study. Climacteric 8:243–250. doi:10.1080/13697130500118050

    Article  PubMed  CAS  Google Scholar 

  19. Schulz KF, Chalmers I, Hayes RJ, Altman DG (1995) Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA 273:408–412. doi:10.1001/jama.273.5.408

    Article  PubMed  CAS  Google Scholar 

  20. Day SJ, Altman DG (2000) Statistics notes: blinding in clinical trials and other studies. BMJ 321:504. doi:10.1136/bmj.321.7259.504

    Article  PubMed  CAS  Google Scholar 

  21. Ernst E, Pittler MH (1997) Alternative therapy bias. Nature 385:480. doi:10.1038/385480c0

    Article  PubMed  CAS  Google Scholar 

  22. Pittler MH, Abbot NC, Harkness EF, Ernst E (2000) Location bias in controlled clinical trials of complementary/alternative therapies. J Clin Epidemiol 53:485–489. doi:10.1016/S0895-4356(99)00220-6

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

M.S. Lee, K.H. Kim and S.M.Choi were supported by the Acupuncture, Moxibustion and Meridian Research Project (K08010) of the Korea Institute of Oriental Medicine.

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Authors and Affiliations

  1. Department of Medical Research, Korea Institute of Oriental Medicine, Daejeon, 305-811, South Korea

    Myeong Soo Lee, Kun-Hyung Kim & Sun-Mi Choi

  2. Complementary Medicine, Peninsula Medical School, Universities of Exeter & Plymouth, Exeter, UK

    Edzard Ernst

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  1. Myeong Soo Lee
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  2. Kun-Hyung Kim
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  4. Edzard Ernst
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Correspondence to Myeong Soo Lee.

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Lee, M.S., Kim, KH., Choi, SM. et al. Acupuncture for treating hot flashes in breast cancer patients: a systematic review. Breast Cancer Res Treat 115, 497–503 (2009). https://doi.org/10.1007/s10549-008-0230-z

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  • DOI: https://doi.org/10.1007/s10549-008-0230-z

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