Breast Cancer Research and Treatment

, Volume 118, Issue 1, pp 1–7 | Cite as

Risk factors for breast cancer from benign breast disease in a diverse population

  • Maria J. Worsham
  • Usha Raju
  • Mei Lu
  • Alissa Kapke
  • Alyssa Botttrell
  • Jingfang Cheng
  • Varsha Shah
  • Adnan Savera
  • Sandra R. Wolman
Preclinical Study


Background The majority of studies have reported risks of breast cancer (BC) from benign breast disease (BBD) in essentially homogenous Caucasian populations. Information on breast cancer risk factors in larger, multi-ethnic populations should facilitate the development of appropriate and targeted risk reduction strategies. Design Cases and controls were drawn from a parent BBD cohort of 4,970 women, 1,341 African–Americans (AA) and 3,629 non-AA who were diagnosed with BBD after examination of an excisional breast biopsy. Risk factors (34 variables) included demographics, lesion types, and epidemiological variables. Results The final multivariable model retained significance (P < 0.05) for lesion risk-level, fibroadenoma, and the interaction of age-by-race. Women with proliferative lesions (no atypia, risk level 2) were 1.7 times more likely to develop BC when compared with women with non-proliferative lesions (OR = 1.7, 95% CI 1.13, 2.42, P = 0.009). Women with atypia (risk level 3) were 3.75 times more likely to develop BC compared to women with non-proliferative lesions (OR = 3.75, 95% CI 1.99, 7.06, P < 0.001). The odds of breast cancer was approximately 35% lower among women with fibroadenoma as compared to women without fibroadenoma (OR = 0.65, 95% CI 0.46, 0.94, P = 0.020). AA women with BBD who were 50 years or older were 2.28 times more likely to develop breast cancer as compared to non-AA women who were less than 50 years old (OR = 2.28, 95% CI 1.34, 3.88, P = 0.002). Conclusion Women with fibroadenoma (nonproliferative or proliferative) were less likely to progress to BC. Older AA women are at greater risk for progression to breast cancer from BBD.


Benign breast disease Progression Risk factors 



This research was supported by NIH CA 70923 (MJW) and ACS EDT-116 (MJW).

Supplementary material

10549_2008_198_MOESM1_ESM.xls (28 kb)
(XLS 28 kb)


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Maria J. Worsham
    • 1
  • Usha Raju
    • 2
  • Mei Lu
    • 3
  • Alissa Kapke
    • 3
  • Alyssa Botttrell
    • 1
    • 4
  • Jingfang Cheng
    • 5
  • Varsha Shah
    • 6
  • Adnan Savera
    • 7
  • Sandra R. Wolman
    • 8
  1. 1.Department of Otolaryngology/Head and Neck SurgeryHenry Ford Health SystemDetroitUSA
  2. 2.Department of PathologyHenry Ford Health SystemDetroitUSA
  3. 3.Department of Biostatistics and Research EpidemiologyHenry Ford Health SystemDetroitUSA
  4. 4.Wayne State UniversityDetroitUSA
  5. 5.Department of Head and Neck SurgeryWayne State School of Medicine, Henry Ford Health SystemDetroitUSA
  6. 6.Royal Gwent HospitalSouth WalesUK
  7. 7.LabMD, Inc.AtlantaUSA
  8. 8.Department of PathologyGeorge Washington UniversityWashingtonUSA

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