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Breast Cancer Research and Treatment

, Volume 112, Issue 3, pp 575–579 | Cite as

Genetic polymorphisms in the DNA repair genes XRCC1, XRCC2 and XRCC3 and risk of breast cancer in Cyprus

  • Maria A. Loizidou
  • Thalia Michael
  • Susan L. Neuhausen
  • Robert F. Newbold
  • Yiola Marcou
  • Eleni Kakouri
  • Maria Daniel
  • Panayiotis Papadopoulos
  • Simos Malas
  • Kyriacos Kyriacou
  • Andreas HadjisavvasEmail author
Epidemiology

Abstract

Population-based studies have reported significant associations between specific genetic polymorphisms and breast cancer susceptibility. A number of studies have demonstrated that common variants of genes involved in the DNA repair pathway act as low penetrance breast cancer susceptibility alleles. We aimed to investigate the association of single nucleotide polymorphisms (SNPs) in the DNA repair genes XRCC1, XRCC2 and XRCC3 and breast cancer in MASTOS, a population-based case–control study of 1,109 Cypriot women with breast cancer diagnosed between 40 and 70 years and 1,177 age-matched healthy controls. Five coding SNPs were genotyped including rs1799782, rs25489 and rs25487 in XRCC1, rs3218536 in XRCC2 and rs861539 in XRCC3. Homozygous XRCC1 280His carriers had an increased risk of breast cancer (odds ratio 4.68; 95% CI 1.01–21.7; P = 0.03). The XRCC2 188His allele was associated with a marginal protective effect for breast cancer (odds ratio 0.79; 95% CI 0.62–1.00; P = 0.05). No significant associations were observed between the other three SNPs and breast cancer. This study suggests that genetic variation in SNPs in XRCC1 and XRCC2 genes may influence breast cancer susceptibility.

Keywords

Breast cancer Case–Control study Cyprus DNA repair Genetic epidemiology Polymorphisms XRCC1 XRCC2 XRCC3 

Notes

Acknowledgments

We thank Rena Papachristoforou for her assistance in data collection. We also thank the patients and the healthy volunteers who participated in MASTOS without whom this research could not have been done. This work is supported by Cyprus Research Promotion Foundation (IPE) grants 0104/13 and 0104/17 and the Cyprus Institute of Neurology and Genetics.

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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Maria A. Loizidou
    • 1
  • Thalia Michael
    • 1
  • Susan L. Neuhausen
    • 2
  • Robert F. Newbold
    • 3
  • Yiola Marcou
    • 4
  • Eleni Kakouri
    • 4
  • Maria Daniel
    • 4
  • Panayiotis Papadopoulos
    • 4
  • Simos Malas
    • 5
  • Kyriacos Kyriacou
    • 1
  • Andreas Hadjisavvas
    • 1
    Email author
  1. 1.Department of Electron Microscope/Molecular PathologyThe Cyprus Institute of Neurology and GeneticsNicosiaCyprus
  2. 2.Department of Epidemiology, School of MedicineUniversity of California IrvineIrvineUSA
  3. 3.Faculty of Life Sciences, Brunel Institute of Cancer Genetics and PharmacogenomicsBrunel UniversityUxbridgeUK
  4. 4.Bank of Cyprus Oncology CenterNicosiaCyprus
  5. 5.Department of OncologyLimassol General HospitalLimassolCyprus

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