Breast Cancer Research and Treatment

, Volume 108, Issue 1, pp 87–92

A Phase 2 study of perifosine in advanced or metastatic breast cancer

  • Natasha B. Leighl
  • Susan Dent
  • Mark Clemons
  • Theodore A. Vandenberg
  • Richard Tozer
  • David G. Warr
  • R. Michael Crump
  • David Hedley
  • Gregory R. Pond
  • Janet E. Dancey
  • Malcolm J. Moore
Clinical Trial

DOI: 10.1007/s10549-007-9584-x

Cite this article as:
Leighl, N.B., Dent, S., Clemons, M. et al. Breast Cancer Res Treat (2008) 108: 87. doi:10.1007/s10549-007-9584-x

Abstract

Background

First- and second-line chemotherapy with anthracyclines and taxanes in metastatic breast cancer yield a modest improvement in survival with potentially significant toxicity. Subsequent lines of chemotherapy yield response rates of 20–25%, with an unknown impact on survival. Perifosine, an oral alkylphospholipid structurally related to miltefosine, has marked activity against breast cancer cell lines and xenograft models, with broad spectrum cellular effects.

Objectives

To determine the efficacy and toxicity of perifosine in patients with metastatic breast cancer patients after up to 2 lines of prior chemotherapy for advanced disease.

Methods

18 patients were enrolled, and 17 treated, using a loading/maintenance dose schedule, (day 1, 300 mg, maintenance 150 mg days 2–21) every 28 days, until disease progression or unacceptable toxicity.

Results

Median age of patients was 54 (28–69), 16/17 were female, ECOG performance status was 0/1 in 16 patients. Fifteen received at least 1 prior chemotherapy regimen for metastatic disease (maximum 2). A median of 2 cycles (range 1–13) was administered per patient. Sixteen were evaluable for response: 2 had SD for 4 cycles, 1 SD for 13 cycles, 13 progressed by cycle 2. Grade 3/4 drug-related non-hematologic toxicities include: diarrhea (2), vomiting (2), nausea (2), fatigue (2) and anorexia (1). No grade 3/4 hematologic toxicities were seen. Median time to progression was 8 weeks (7–15 weeks).

Conclusion

No objective responses were seen in this group of pretreated metastatic breast cancer patients. Disease stabilization was observed in 19% at 2 months.

Keywords

Metastatic breast cancer Perifosine Alkylphospholipid Phase 2 Taxane-refractory Anthracycline-refractory 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Natasha B. Leighl
    • 1
  • Susan Dent
    • 2
  • Mark Clemons
    • 2
  • Theodore A. Vandenberg
    • 2
  • Richard Tozer
    • 2
  • David G. Warr
    • 2
  • R. Michael Crump
    • 2
  • David Hedley
    • 2
  • Gregory R. Pond
    • 1
  • Janet E. Dancey
    • 3
  • Malcolm J. Moore
    • 2
  1. 1.Medical OncologyPrincess Margaret Hospital/University Health NetworkTorontoCanada
  2. 2.Princess Margaret Hospital Phase 2 ConsortiumTorontoCanada
  3. 3.National Cancer Institute Cancer Therapy Evaluation ProgramBethesdaUSA

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