Breast Cancer Research and Treatment

, Volume 107, Issue 2, pp 289–301 | Cite as

A randomized controlled trial of a decision aid for women considering genetic testing for breast and ovarian cancer risk

  • Claire E. Wakefield
  • Bettina Meiser
  • Judi Homewood
  • Michelle Peate
  • Alan Taylor
  • Elizabeth Lobb
  • Judy Kirk
  • Mary-Anne Young
  • Rachel Williams
  • Tracy Dudding
  • Kathy Tucker
  • the AGenDA Collaborative Group
Preclinical Study/Clinical Trial/Epidemiology/Invited Commentary

Abstract

Purpose

To measure the effectiveness of a tailored decision aid (DA) designed to help women make informed decisions about genetic testing for breast/ovarian cancer risk.

Methods

A total of 145 women were randomized to receive the DA or a control pamphlet at the end of their first genetic counseling consultation. Of these, 120 (82.8%) completed two questionnaires, 1 week and 6 months post-consultation.

Results

While the DA had no effect on informed choice, post-decisional regret or actual genetic testing decision, the trial showed that women who received the DA had higher knowledge levels and felt more informed about genetic testing than women who received the control pamphlet (χ2(2) = 6.82; P = 0.033; χ2(1) = 4.86; P = 0.028 respectively). The DA also helped women who did not have blood drawn at their first consultation to clarify their values with regards to genetic testing (χ2(1) = 5.27; P = 0.022). Women who received the DA were less likely to share the information with other family members than women in the control condition (χ2(1) = 8.78; P = 0.003).

Conclusions

Decision aids are an effective decision-support strategy for women considering genetic testing for breast/ovarian cancer risk, and are most effective before the patient has made a decision, which is generally at the point of having blood drawn.

Keywords

Decision aid Patient education Genetic testing Hereditary breast cancer Hereditary ovarian cancer 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Claire E. Wakefield
    • 1
    • 2
    • 3
  • Bettina Meiser
    • 2
    • 3
  • Judi Homewood
    • 1
  • Michelle Peate
    • 2
  • Alan Taylor
    • 1
  • Elizabeth Lobb
    • 4
    • 5
  • Judy Kirk
    • 6
  • Mary-Anne Young
    • 7
  • Rachel Williams
    • 8
  • Tracy Dudding
    • 9
  • Kathy Tucker
    • 2
    • 10
  • the AGenDA Collaborative Group
  1. 1.Department of PsychologyMacquarie UniversitySydneyAustralia
  2. 2.Psychosocial Research Group (PRG), Department of Medical OncologyPrince of Wales HospitalRandwick, SydneyAustralia
  3. 3.School of PsychiatryUniversity of New South WalesRandwick, SydneyAustralia
  4. 4.WA Centre for Cancer & Palliative Care, School of Nursing, Midwifery and Postgraduate MedicineEdith Cowan UniversityPerthAustralia
  5. 5.Medical Psychology Research UnitThe University of SydneyCamperdownAustralia
  6. 6.Familial Cancer ServiceWestmead HospitalWestmeadAustralia
  7. 7.Familial Cancer CentrePeter MacCallum Cancer CentreMelbourneAustralia
  8. 8.Family Cancer ClinicSt Vincent’s HospitalDarlinghurst, SydneyAustralia
  9. 9.Hunter Family Cancer ServiceHunter New England HealthNewcastleAustralia
  10. 10.Prince of Wales Clinical SchoolUniversity of NSWRandwick, SydneyAustralia

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