Breast Cancer Research and Treatment

, Volume 107, Issue 1, pp 79–86

Prophylactic mastectomy in familial breast carcinoma. What do the pathologic findings learn us?

  • Karin Leunen
  • Maria Drijkoningen
  • Patrick Neven
  • Maria-Rose Christiaens
  • Chantal Van Ongeval
  • Eric Legius
  • Frédéric Amant
  • Patrick Berteloot
  • Ignace Vergote
Clinical Trial

DOI: 10.1007/s10549-007-9525-8

Cite this article as:
Leunen, K., Drijkoningen, M., Neven, P. et al. Breast Cancer Res Treat (2008) 107: 79. doi:10.1007/s10549-007-9525-8

Abstract

Objective To evaluate the indications, techniques and pathologic findings of prophylactic mastectomy (pME). Methods Retrospective study of patients with a strong family history of breast cancer (and ovarian cancer) or with proven BRCA mutation. Results Between January 1995 and December 2005, sixty seven patients underwent pME: 15% had a BRCA1 mutation, 31% had a BRCA2 mutation and 33% had a strong family history but without proven BRCA mutation and in 21% mutation analysis was not performed. Fifty eight percent had a personal history of breast cancer of which 84% previously underwent a unilateral mastectomy as part of their treatment. The median time to decision from previous treatment for breast carcinoma to pME was 46 months. Mean age at pME was 43 years. Pathologic examination of the pME specimens revealed invasive and/or in situ carcinoma in 19% (13/67). Atypical ductal/lobular hyperplasia (ADH/ALH) or flat epithelial atypia (FEA) were present in another 3%. Conclusion Twenty two percent of women at high risk for breast cancer presented at the time of pME with invasive carcinoma or intra-epithelial neoplasia undetected by imaging and clinical examination.

Keywords

Prophylactic mastectomy Pathologic findings BRCA Breast-ovarian cancer families 

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Karin Leunen
    • 1
  • Maria Drijkoningen
    • 5
  • Patrick Neven
    • 1
  • Maria-Rose Christiaens
    • 2
  • Chantal Van Ongeval
    • 3
  • Eric Legius
    • 4
  • Frédéric Amant
    • 1
  • Patrick Berteloot
    • 1
  • Ignace Vergote
    • 1
  1. 1.Department of Obstetrics and Gynaecology, Division of Gynaecologic OncologyMultidisciplinary Breast Centre, University Hospitals LeuvenLeuvenBelgium
  2. 2.Department of SurgeryMultidisciplinary Breast Centre, University Hospitals LeuvenLeuvenBelgium
  3. 3.Department of RadiologyMultidisciplinary Breast Centre, University Hospitals LeuvenLeuvenBelgium
  4. 4.Department of Human Genetics Catholic University LeuvenLeuvenBelgium
  5. 5.Department of PathologyMultidisciplinary Breast Centre, University Hospitals LeuvenLeuvenBelgium

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