Breast Cancer Research and Treatment

, Volume 103, Issue 3, pp 361–369

Diet quality and BRCA-associated breast cancer risk

Original paper

Abstract

Although it has been suggested that dietary energy intake restriction may be related to reduced BRCA-associated breast cancer (BC) risk, it is currently not known whether overall diet quality could predict the BC risk among women with deleterious mutations in BRCA1 and BRCA2 (BRCA) genes who already have an elevated BC risk. To assess possible relationships between diet quality, reflected by the Alternate Healthy Eating Index (AHEI), the Diet Quality Index-Revised (DQI-R), the alternate Mediterranean Diet Index (aMED), the Canadian Healthy Eating Index (CHEI), and BRCA-associated BC risk, a case-control study was carried out within a cohort of 80 French-Canadian families with 250 members involving 89 carriers of BRCA genes affected by BC, 48 non-affected carriers and 46 non-affected non-carriers. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in unconditional logistic regression models. After adjustment for age, physical activity and total energy intake, we did not detect any association between the AHEI or aMED and BC. However, a strong and significant inverse relationship was apparent between the DQI-R and CHEI and BRCA-associated BC risk. ORs comparing the highest and lowest tertiles of diet quality scores were 0.35 (95%CI = 0.12–1.02; p = 0.034 for trend) for the DQI-R and 0.18 (95%CI = 0.05–0.68; p = 0.006 for trend) for the CHEI, respectively. These inverse associations were not the result of a link with any specific component of the diet quality indexes. These results suggest that dietary guidelines reflected by the DQI-R and CHEI may constitute preventive strategies for reducing BRCA-associated BC risk.

Keywords

Breast cancer BRCA Food group Nutrient Diet Nutrition Prevention Epidemiology 

References

  1. 1.
    Canadian Cancer Statistics. http://www.cancer.ca. Cited 2 June 2006Google Scholar
  2. 2.
    Antoniou AC, Pharoah PD, Narod S et al (2005) Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies. J Med Genet 42:602–603PubMedCrossRefGoogle Scholar
  3. 3.
    World Cancer Research Fund, American Institute for Cancer Research Fund, Nutrition and the Prevention of Cancer (1997) A global perspective. American Institute for Cancer Research, Washington, DCGoogle Scholar
  4. 4.
    Key TJ, Schatzkin A, Willett WC et al (2004) Diet, nutrition and the prevention of cancer. Public Health Nutr 7:187–200PubMedCrossRefGoogle Scholar
  5. 5.
    Nkondjock A, Robidoux A, Paredes Y et al (2006) Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians. Breast Cancer Res Treat 98:285–294PubMedCrossRefGoogle Scholar
  6. 6.
    Haines PS, Siega-Riz AM, Popkin BM (1999) The Diet Quality Index revised: a measurement instrument for populations. J Am Diet Assoc 99:697–704PubMedCrossRefGoogle Scholar
  7. 7.
    McCullough ML, Feskanich D, Stampfer MJ et al (2002) Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr 76:1261–1271PubMedGoogle Scholar
  8. 8.
    Trichopoulou A, Costacou T, Bamia C et al (2003) Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 348:2599–2608PubMedCrossRefGoogle Scholar
  9. 9.
    Newby PK, Hu FB, Rimm EB et al (2003) Reproducibility and validity of the Diet Quality Index Revised as assessed by use of a food-frequency questionnaire. Am J Clin Nutr 78:941–949PubMedGoogle Scholar
  10. 10.
    Fung TT, McCullough ML, Newby PK et al (2005) Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction. Am J Clin Nutr 82:163–173PubMedGoogle Scholar
  11. 11.
    Fung TT, Hu FB, McCullough ML et al (2006) Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal women. J Nutr 136:466–472PubMedGoogle Scholar
  12. 12.
    Tonin PN, Perret C, Lambert JA et al (2001) Founder BRCA1 and BRCA2 mutations in early-onset French Canadian breast cancer cases unselected for family history. Int J Cancer 95:189–193PubMedCrossRefGoogle Scholar
  13. 13.
    Aretini P, D’Andrea E, Pasini B et al (2003) Different expressivity of BRCA1 and BRCA2: analysis of 179 Italian pedigrees with identified mutation. Breast Cancer Res Treat 81:71–79PubMedCrossRefGoogle Scholar
  14. 14.
    Tonin PM, Mes-Masson AM, Narod SA et al (1999) Founder BRCA1 and BRCA2 mutations in French Canadian ovarian cancer cases unselected for history family. Clin Genet 55:318–324PubMedCrossRefGoogle Scholar
  15. 15.
    Jain M, Howe GR, Rohan T (1996) Dietary assessment in epidemiology: comparison on food frequency and a diet history questionnaire with a 7-day food record. Am J Epidemiol 143:953–960PubMedGoogle Scholar
  16. 16.
    Jain M, Miller AB, To T (1994) Premorbid diet and the prognosis of women with breast cancer. J Natl Cancer Inst 86:1390–1397PubMedCrossRefGoogle Scholar
  17. 17.
    Ghadirian P, Jain M, Ducic S et al (1998) Nutritional factors in the aetiology of multiple sclerosis: a case-control study in Montreal, Canada. Int J Epidemiol 27:845–852PubMedCrossRefGoogle Scholar
  18. 18.
    US Department of Agriculture (1992) Food guide pyramid: a guide to daily food choices. US Department of Agriculture, Human Nutrition Information Service, Home and Garden Bulletin No. 232, Washington, DCGoogle Scholar
  19. 19.
    US Department of Agriculture and US Department of Health and Human Services (1995) Nutrition and your health: dietary guidelines for Americans; 5th ed. US Departments of Agriculture and Health and Human Services, Home and Garden Bulletin No. 252, Washington, DCGoogle Scholar
  20. 20.
    Canada’s Food Guide to Healthy Eating. http://www.hc-sc.gc.ca/fn-an/food-guide-aliments/ Cited 24 May 2006Google Scholar
  21. 21.
    Wayne SJ, Baumgartner K, Baumgartner RN et al (2006) Diet quality is directly associated with quality of life in breast cancer survivors. Breast Cancer Res Treat 96:227–232PubMedCrossRefGoogle Scholar
  22. 22.
    Tangney CC, Young JA, Murtaugh MA et al (2002) Self-reported dietary habits, overall dietary quality and symptomatology of breast cancer survivors: a cross-sectional examination. Breast Cancer Res Treat 71:113–123PubMedCrossRefGoogle Scholar
  23. 23.
    Petri AL, Tjonneland A, Gamborg M et al (2004) Alcohol intake, type of beverage, and risk of breast cancer in pre- and postmenopausal women. Clin Exp Res 28:1084–1090CrossRefGoogle Scholar
  24. 24.
    Singletary KW, Gapstur SM (2001) Alcohol and breast cancer: review of epidemiologic and experimental evidence and potential mechanisms. JAMA 286:2143–2151PubMedCrossRefGoogle Scholar
  25. 25.
    Dumitrescu RG, Shields PG (2005) The etiology of alcohol-induced breast cancer. Alcohol 35:213–225PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2006 2006

Authors and Affiliations

  1. 1.Epidemiology Research Unit, Research CentreCentre hospitalier de l’Université de Montréal (CHUM)―Hôtel-DieuMontrealCanada
  2. 2.Department of NutritionUniversity of MontrealMontrealCanada

Personalised recommendations