Breast Cancer Research and Treatment

, Volume 101, Issue 3, pp 349–353

Metaplastic carcinoma of the breast, an unusual disease with worse prognosis: the experience of the European Institute of Oncology and review of the literature

  • Alberto Luini
  • Marisel Aguilar
  • Giovanna Gatti
  • Roberta Fasani
  • Edoardo Botteri
  • Jack Antonio Diaz Brito
  • Patrick Maisonneuve
  • Anna Rita Vento
  • Giuseppe Viale
REVIEW

Abstract

Background

Metaplastic carcinoma of the breast is a rare form of breast cancer and has an uncertain prognostic significance. The purpose of the present study was to compare the clinical course, and prognosis, between this type of tumor and poorly differentiated ductal carcinoma.

Patients and methods

We analyzed 37 cases of metaplastic carcinoma of the breast treated at our institution (European Institute of Oncology in Milan, Italy) between 1997 and 2004, comparing them with 72 cases (control group) of poorly differentiated ductal carcinoma. All 109 patients had negative receptors and were G3 at final histology. The control cases were matched according to year of surgery, pT (pT1 vs. pT2/3/4), and pN (absent vs. present).

Results

Of the 37 patients, eleven died from disease progression, eight developed metastatic disease and two experienced local recurrence. In the control group (72 patients) we observed three deaths due to disease progression, 13 distant metastases, and two local recurrences.

Conclusion

The overall survival in the metaplastic carcinoma group was significantly worse than in the control group. As regards to disease-free survival, there was no statistically significant difference between the two groups.

Keywords

Metaplastic carcinoma of the breast Prognosis Treatment Review 

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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Alberto Luini
    • 1
    • 2
  • Marisel Aguilar
    • 1
  • Giovanna Gatti
    • 1
    • 3
  • Roberta Fasani
    • 4
  • Edoardo Botteri
    • 5
  • Jack Antonio Diaz Brito
    • 1
  • Patrick Maisonneuve
    • 5
  • Anna Rita Vento
    • 1
  • Giuseppe Viale
    • 4
    • 2
  1. 1.Division of Breast SurgeryEuropean Institute of OncologyMilanItaly
  2. 2.University of Milan School of MedicineMilanItaly
  3. 3.Postgraduate School of General SurgeryUniversity of PerugiaPerugiaItaly
  4. 4.Division of PathologyEuropean Institute of OncologyMilanItaly
  5. 5.Division of Epidemiology and BiostatisticsEuropean Institute of OncologyMilanItaly

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