Breast Cancer Research and Treatment

, Volume 99, Issue 3, pp 301–307 | Cite as

Ductoscopy and intraductal vacuum assisted biopsy in women with pathologic nipple discharge

  • Michael HünerbeinEmail author
  • Matthias Raubach
  • Bernhard Gebauer
  • Wolfgang Schneider
  • Peter M. Schlag
Clinical trial



Fiberoptic ductoscopy is increasingly used to evaluate pathologic nipple discharge. A major limitation of this technique is the inability to obtain tissue samples from suspicious intraductal lesions. We present a novel technique for ductoscopic biopsy of intraluminal tumors.


From 2002 to 2005 ductoscopy was performed in 38 women with nipple discharge using a rigid gradient index microendoscope (diameter 0.7 mm) and a special needle for intraductal vacuum assisted biopsy. Results of preoperative biopsy were correlated with the histology of the resection specimen


Cannulation of the discharging duct was successful in 37 of 38 patients (97%). Intraductal lesions were diagnosed in 29 women (78%). The sensitivity of ductoscopy and galactography in the detection of intraductal lesion was comparable (96% vs. 89%). Ductoscopic biopsy of intraductal lesions was technically successful in all but one case. Generally, the quality of the biopsy samples was good. Diagnostic biopsy samples were obtained in 26 of 28 patients (93%). Two samples contained necrosis and were considered to be non-representative. Histological analysis of the biopsy specimens showed 22 papilloma, 2 in situ carcinoma and 2 invasive carcinoma. Histology of the resection specimens confirmed the diagnosis in all cases, but there was one case with additional carcinoma lobulare in situ.


Ductoscopic vacuum assisted biopsy is a new technique for tissue sampling of intraductal breast lesions. This method may improve preoperative evaluation of pathologic nipple discharge in selected patients, but it should not be considered as a method for screening of early breast cancer.


Breast cancer Ductoscopy Intraductal biopsy Intraductal disease 


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Copyright information

© Springer Science+Business Media B.V. 2006

Authors and Affiliations

  • Michael Hünerbein
    • 1
    • 4
    Email author
  • Matthias Raubach
    • 1
  • Bernhard Gebauer
    • 3
  • Wolfgang Schneider
    • 2
  • Peter M. Schlag
    • 1
  1. 1.Department of Surgery and Surgical OncologyCharité Universitätsmedizin BerlinBerlinGermany
  2. 2.Department of PathologyCharité Universitätsmedizin BerlinBerlinGermany
  3. 3.Department of RadiologyCharité Universitätsmedizin BerlinBerlinGermany
  4. 4.Department of Surgery and Surgical OncologyBerlinGermany

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