Breast Cancer Research and Treatment

, Volume 98, Issue 2, pp 199–208

Fruits, vegetables, and micronutrient intake in relation to breast cancer survival

  • Brian N. Fink
  • Mia M. Gaudet
  • Julie A. Britton
  • Page E. Abrahamson
  • Susan L. Teitelbaum
  • Judith Jacobson
  • Paula Bell
  • Joyce A. Thomas
  • Geoffrey C. Kabat
  • Alfred I. Neugut
  • Marilie D. Gammon
Epidemiology

Summary

Objective

To determine whether fruit, vegetable, and micronutrient intake 1 year prior to breast cancer diagnosis is associated with a reduction in the subsequent risk of all-cause or breast cancer-specific mortality.

Methods

Follow-up data from 1,235 invasive breast cancer cases age 25–98 years from the Long Island Breast Cancer Study Project were analyzed. At the 1996–1997 case-control interview, respondents completed a food frequency questionnaire, which assessed dietary intake of fruits, vegetables, and vitamin supplement use in the previous 12 months. All-cause mortality (n=186 deaths) and breast cancer-specific mortality status (n=125 deaths, 67.2%) were determined through December 31, 2002.

Results

Hazard ratios (HRs) for all-cause mortality were insignificantly reduced for intake of any fruits, fruit juices, and vegetables (HR=0.68, 95% CI: 0.42–1.09) and leafy vegetables (HR=0.72, 95% CI: 0.41–1.24) among post-menopausal women only. Both of these associations were more pronounced among those with ER+PR+ tumors (HR=0.54, 95% CI: 0.27–1.10, and HR=0.66, 95% CI: 0.33–1.31, respectively). Similar associations were observed for breast cancer-specific mortality.

Conclusions

In a cohort of women diagnosed with breast cancer, higher intake of fruits, vegetables, and micronutrients was associated with a non-significant survival advantage in post-menopausal women only.

Keywords

antioxidants, breast cancer mortality, follow-up study, fruits, Long Island, survival, vegetables 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Brian N. Fink
    • 1
    • 6
  • Mia M. Gaudet
    • 1
  • Julie A. Britton
    • 2
  • Page E. Abrahamson
    • 1
  • Susan L. Teitelbaum
    • 2
  • Judith Jacobson
    • 3
  • Paula Bell
    • 1
  • Joyce A. Thomas
    • 3
  • Geoffrey C. Kabat
    • 4
  • Alfred I. Neugut
    • 3
    • 5
  • Marilie D. Gammon
    • 1
  1. 1.Department of Epidemiology, School of Public HealthUniversity of North CarolinaChapel HillUSA
  2. 2.Department of Community and Preventive MedicineMt. Sinai School of MedicineNew YorkUSA
  3. 3.Department of Epidemiology, Joseph L. Mailman School of Public HealthColumbia UniversityNew YorkUSA
  4. 4.Department of Preventive Medicine, School of MedicineState University of New YorkStony BrookUSA
  5. 5.Department of Medicine, College of Physicians & SurgeonsColumbia UniversityNew YorkUSA
  6. 6.Department of Epidemiology, School of Public HealthUniversity of North CarolinaChapel HillUSA

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