Prospective study of electrical impedance scanning for identifying young women at risk for breast cancer
- 142 Downloads
One way to improve the cost-benefit ratio for breast cancer screening in younger women is to identify those at high-risk of breast cancer and manage them in an optimal manner. The purpose of this study is to evaluate the sensitivity and specificity of Electrical Impedance Scanning (EIS) for identifying young women who are at risk for having breast cancer and should be followed with directed imaging technologies.
A prospective, observational, two-arm, multi-site clinical trial was performed on women aged 30–45 years. The ‘Sensitivity Arm’ included Clinical Breast Examinations (CBE) and EIS (T-Scan™ 2000ED) on 189 women prior to scheduled breast biopsy. The ‘Specificity Arm’ included 1361 asymptomatic women visiting clinics for routine annual well-woman examination. Sensitivity and specificity were determined. Relative probability for a woman with a positive EIS examination was computed and compared with other approaches commonly used to define ‘high-risk’ in this population.
Fifty of 189 women in the Sensitivity arm had verified cancers, 19 of whom had positive EIS examination resulting in sensitivity of 38% (19/50). Of the 1361 women in the Specificity arm, 67 had positive EIS examination resulting in a specificity of 95% (1294/1361). The relative probability of a woman with a positive EIS examination was 7.68, which compares favorably with other established risk identifiers (e.g. two first-degree relatives with breast cancer or atypical ductal hyperplasia).
EIS may have an important role as a screening tool for identifying young women that should be followed more closely with advanced imaging technologies for early detection of breast cancer.
Keywordselectrical impedance screening breast cancer
- 1.Committee on New Approaches to Early Detection and Diagnosis of Breast Cancer, Saving Women’s Lives (2004) Strategies for Improving Breast Cancer Detection and Diagnosis In: Joy JE, Penhoet EE, Petitti DB, (eds). Institute of Medicine and National Research Council of the National Academies National Academy Press Washington DCGoogle Scholar
- 4.American Cancer Society. Cancer Facts & Figures 2004. [monograph online] 2004: Available from URL: http:// www.cancer.org/statistics/index.html? Language=English [Accessed on August 31, 2004]Google Scholar
- 6.Kuhl CK, High-risk screening: multi-modality surveillance of women at high risk for breast cancer (proven or suspected carriers of a breast cancer susceptibility gene)J Exp Clin Cancer Res2002; 21(3 Suppl):S103–S106Google Scholar
- 12.Fricke H, Morse S, The electric capacity of tumors of the breast J Cancer Res16:310–376. 1926Google Scholar
- 22.Scholz B, Anderson R, On electrical impedance scanning – principles and simulationsElectromedica2000; 68:35–44Google Scholar
- 41.U.S. Food and Drug Administration (FDA). TransScan T-Scan 2000 – P970033. Summary of Safety and Effectiveness. [monograph online] April 16, 1999; Available from URL: http://www.fda.gov/cdrh/pdf/p970033.html [Accessed on September 1, 2004]Google Scholar
- 42.Davies RJ, Quinn DA, Davisson TH, Impedance spectroscopy characterizes the electrical signature of benign and malignant breast epitheliumBreast Cancer Res Treat2004; 88:S221Google Scholar
- 43.Davies RJ, Quinn DA, Davisson TH, Alterations in ionic transport and conductance during malignancy in breast epitheliumBreast Cancer Res Treat2004; 88:S222Google Scholar
- 46.Krieger N, Hiatt RA, Risk of breast cancer after benign breast diseaseAm J Epidemiol1992; 136:619–631Google Scholar