Breast Cancer Research and Treatment

, Volume 92, Issue 3, pp 199–206

Breast Cancer Treatment and Cognitive Functioning: Current Status and Future Challenges in Assessment

  • Steven A. Castellon
  • Daniel H. S. Silverman
  • Patricia A. Ganz
Invited Commentary

Keywords

adjuvant therapy breast cancer chemotherapy cognitive functioning late effects neuroimaging neuropsychological 

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References

  1. 1.
    Ahles, TA, Saykin, AJ 2001Cognitive effects of standard-dose chemotherapy in patients with cancerCancer Invest19821820CrossRefPubMedGoogle Scholar
  2. 2.
    Meyers, CA 2000Neurocognitive dysfunction in cancer patientsOncology147579PubMedGoogle Scholar
  3. 3.
    Jemal, A, Murray, T, Ward, E, Samuels, A, Tiwari, RC, Ghafoor, A 2005Cancer Statistics, 2005CA: A Cancer J Clin551030Google Scholar
  4. 4.
    Castellon, SA, Ganz, P 2001Cognitive function following adjuvant treatment for breast cancerOncology15622624Google Scholar
  5. 5.
    Ganz, PA, Rowland, JH, Desmond, K, Meyerowitz, BE, Wyatt, GE 1998Life after breast cancer: understanding women’s health-related quality of life and sexual functioningJ Clin Oncol16501514PubMedGoogle Scholar
  6. 6.
    Ganz, PA, Desmond, KA, Leedham, B, Rowland, JH, Meyerowitz, BE, Belin, TR 2002Quality of life in long-term, disease-free survivors of breast cancer: a follow-up studyJ Natl Cancer Inst943949PubMedGoogle Scholar
  7. 7.
    Phillips, K, Bernhard, J 2003Adjuvant breast cancer treatment and cognitive function: current knowledge and research directionsJ Natl Cancer Inst95190197PubMedGoogle Scholar
  8. 8.
    Bremner, JD, Randall, P, Scott, TM, Bronen, RA, Seibyl, JP, Southwick, SM, Delaney, RC, McCarthy, G, Charney, DS, Innis, RB 1995aMRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorderAm J Psychiatry152973981Google Scholar
  9. 9.
    Bremner, JD, Krystal, JH, Southwick, SM, Charney, DS 1995bFunctional neuroanatomical correlates of the effects of stress on memoryJ Trauma Stress8527553Google Scholar
  10. 10.
    Gurvits, TV, Shenton, M, Hokama, H, Ohta, H, Lasko, N, Gilbertson, M, Orr, SP, Kikinis, R, Jolesz, F, McCarley, RW, Pitman, RK 1996Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorderBiol Psychiatr4010911099CrossRefGoogle Scholar
  11. 11.
    Ahles, TA, Saykin, AJ, Furstenberg, C, Cole, B, Mott, L, Skalla, K, Whedon, MB, Bivens, S, Mitchell, T, Greenberg, ER, Silberfarb, PM 2002Neuropsychologic impact of standard-dose systemic chemotherapy in long-term survivors of breast cancer and lymphomaJ Clin Oncol20485493CrossRefPubMedGoogle Scholar
  12. 12.
    Brezden, CB, Phillips, KA, Abdolell, M, Bunston, T, Tannock, IF 2000Cognitive function in breast cancer patients receiving adjuvant chemotherapyJ Clin Oncol1826952701PubMedGoogle Scholar
  13. 13.
    Castellon, SA, Ganz, P, Bower, J, Petersen, L, Abraham, L, Greendale, GA 2004Neurocognitive performance in breast cancer survivors exposed to adjuvant chemotherapy and tamoxifenJ Clin Exp Neuropsychol26955969PubMedGoogle Scholar
  14. 14.
    Dam, FS, Schagen, SB, Muller, MJ, Boogerd, W, vd Wall, E, Droogleever Fortuyn, ME, Rodenhuis, S 1998Impairment of cognitive function in women receiving adjuvant treatment for high-risk breast cancer: high-dose versus standard-dose chemotherapyJ Natl Cancer Inst90210218CrossRefPubMedGoogle Scholar
  15. 15.
    Tchen, N, Juffs, HG, Downie, FP, Qi-Long, Y, Hu, H, Chemerynsky, I, Clemons, M, Crump, M, Goss, PE, Warr, D, Tweedale, ME, Tannock, IF 2003Cognitive function, fatigue, and menopausal symptoms in women receiving adjuvant chemotherapy for breast cancerJ Clin Oncol2141754183CrossRefPubMedGoogle Scholar
  16. 16.
    Wefel, JS, Lenzi, R, Theriault, RL, Meyers, CA 2004The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trialCancer10022922299CrossRefPubMedGoogle Scholar
  17. 17.
    Budson, AE, Price, BH 2005Memory dysfunctionN Engl J Med352692699CrossRefPubMedGoogle Scholar
  18. 18.
    Schacter DL, Wagner AD, Buckner RL: Memory systems of 1999. In: Tulving E, Craik FM (eds) The Oxford Handbook of Memory. Oxford University Press, New York, 2000Google Scholar
  19. 19.
    Squire, LR, Zola, SM 1996Structure and function of declarative and non-declarative memory systemsProc Natl Acad Sci USA931351513522CrossRefPubMedGoogle Scholar
  20. 20.
    Bottino, CM, Castro, CC, Gomes, RL, Buchpiguel, CA, Marchetti, RL, Neto, MR 2002Volumetric MRI measurements can differentiate Alzheimer’s disease, mild cognitive impairment, and normal agingInt Psychogeriatr145972CrossRefPubMedGoogle Scholar
  21. 21.
    Santi, S, Leon, MJ, Rusinek, H, Convit, A, Tarshish, CY, Roche, A, Tsui, WH, Kandil, E, Boppana, M, Daisley, K, Wang, GJ, Schlyer, D, Fowler, J 2001Hippocampal formation glucose metabolism and volume losses in MCI and ADNeurobiol Aging2252939CrossRefPubMedGoogle Scholar
  22. 22.
    Du, AT, Schuff, N, Amend, D, Laakso, MP, Hsu, YY, Jagust, WJ, Yaffe, K, Kramer, JH, Reed, B, Norman, D, Chui, HC, Weiner, MW 2001Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer’s diseaseJ Neurol Neurosurg Psychiatry71441447CrossRefPubMedGoogle Scholar
  23. 23.
    Galton, CJ, Patterson, K, Graham, K, Lambon-Ralph, MA, Williams, G, Antoun, N, Sahakian, BJ, Hodges, JR 2001Differing pattern of temporal atrophy in Alzheimer’s disease and semantic dementiaNeurology57216225PubMedGoogle Scholar
  24. 24.
    Jack, CR,Jr, Shiung, MM, Gunter, JL, O’Brien, PC, Weigand, SD, Knopman, DS, Boeve, BF, Ivnik, RJ, Smith, GE, Cha, RH, Tangalos, EG, Petersen, RC 2004Comparison of different MRI brain atrophy rate measures with clinical disease progression in ADNeurology62591600PubMedGoogle Scholar
  25. 25.
    Killiany, RJ, Hyman, BT, Gomez-Isla, T, Moss, M, Kikinis, R, Jolesz, F, Tanzi, R, Jones, K, Albert, MS 2002MRI measures of entorhinal cortex vs hippocampus in preclinical ADNeurology5811881196PubMedGoogle Scholar
  26. 26.
    Silverman, DH, Dy, CJ, Castellon, SA, Pio, BS, Abraham, L, Waddell, K, Phelps, ME, Ganz, PA 2004Altered frontocortical and basal ganglia activity in chemotherapy and tamoxifen-treated breast cancer survivors 5 to 10 years after end of chemotherapyJ Nucl Med4567Google Scholar
  27. 27.
    Saykin, AJ, Ahles, TA, McDonald, BC 2003Mechanisms of chemotherapy-induced cognitive disorders: neuropsychological, pathophysiological, and neuroimaging perspectivesSemin Clin Neuropsychiatry8201216CrossRefPubMedGoogle Scholar
  28. 28.
    Wagner L, Sweet J, Cella D, Havlin K, Forrestal S, Parrish T, Gitelman DR: 2004. The performance of cognitively impaired oncology patients and normal controls on functional MRI. Paper presented at the annual meeting of the American Society of Clinical Oncology, New Orleans, LA.Google Scholar
  29. 29.
    Eberling, JL, Wu, C, Tong-Turnbeaugh, R, Jagust, WJ 2004Estrogen and Tamoxifen-associated effects on brain structure and functionNeuroimage21364371CrossRefPubMedGoogle Scholar
  30. 30.
    Schagen, SB, Dam, FS, Muller, MJ, Boogerd, W, Lindeboom, J, Bruning, PF 1999Cognitive deficits after postoperative adjuvant chemotherapy for breast carcinomaCancer85640650CrossRefPubMedGoogle Scholar
  31. 31.
    Wieneke, MH, Dienst, ER 1995Neuropsychological assessment of cognitive functioning following chemotherapy for breast cancerPsychooncology46166Google Scholar
  32. 32.
    Schagen, SB, Muller, MJ, Boogerd, W, Rosenbrand, RM, Rhijn, D, Rodenhuis, S, Dam, FS 2002Late effects of adjuvant chemotherapy on cognitive function: a follow-up study in breast cancer patientsAnn Oncol1313871397CrossRefPubMedGoogle Scholar
  33. 33.
    Chelebowski, RT 2000Reducing the risk of breast cancerN Engl J Med343191198CrossRefPubMedGoogle Scholar
  34. 34.
    Fisher, B Costantino, JP Wickerham, DL Redmond, CK Kavanah, M Cronin, W Vogel, A Robidoux, N Dimitrov, J Atkins, M Daly, S Wieand, E Tan-Chiu, L Ford, N Wolmark,  other National Surgical Adjuvant Breast and Bowel Project Investigators1998Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 StudyJ Natl Cancer Inst9013711388PubMedGoogle Scholar
  35. 35.
    Asthana, S, Baker, LD, Craft, S, Stanczyk, FZ, Veith, RC, Raskind, MA, Plymate, SR 2001High-dose estradiol improves cognition for women with AD: results of a randomized studyNeurology57605612PubMedGoogle Scholar
  36. 36.
    Maki, PM, Resnick, SM 2000Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognitionNeurobiol Aging21373383CrossRefPubMedGoogle Scholar
  37. 37.
    Shaywitz, SE, Shaywitz, BA, Pugh, KR, Fulbright, RK, Skudlarski, P, Mencl, WE, Constable, RT, Naftolin, F, Palter, SF, Marchione, K, Katz, L, Shankweiler, DP, Fletcher, JM, Lacadie, C, Keltz, M, Gore, JC 1999Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasksJAMA28111971202CrossRefPubMedGoogle Scholar
  38. 38.
    Sherwin, B 1997Estrogen effects on cognition in menopausal womenNeurology72126Google Scholar
  39. 39.
    Sherwin, B 1999Can estrogen keep you smart? Evidence from clinical studiesJ Psychiatry Neurosci24315321PubMedGoogle Scholar
  40. 40.
    Grodstein, F, Chen, J, Pollen, DA, Albert, MS, Wilson, RS, Folstein, MF, Evans, DA, Stampfer, MJ 2000Postmenopausal hormone therapy and cognitive function in healthy older womenJ Am Geriatr Soc48746752PubMedGoogle Scholar
  41. 41.
    Sumner, BE, Grant, KE, Rosie, R, Hegele-Hartung, C, Fritzemeier, KH, Fink, G 1999Effects of tamoxifen on serotonin transporter and 5-hydroxytryptamine (2A) receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacementBrain Res Mol Brain Res7311928CrossRefPubMedGoogle Scholar
  42. 42.
    Arpels, JC 1996The female brain hypoestrogenic continuum from premenopausal syndrome to menopauseJ Reprod Med41633639PubMedGoogle Scholar
  43. 43.
    Jenkins, V, Shilling, V, Fallowfield, L, Howell, A, Hutton, S 2004Does hormone therapy for the treatment of breast cancer have a detrimental effect on memory and cognition? A pilot studyPsycho-Oncology136166CrossRefPubMedGoogle Scholar
  44. 44.
    Paganini-Hill, A, Clark, LJ 2000Preliminary assessment of cognitive function in breast cancer patients treated with tamoxifenBreast Cancer Res Treat64165176CrossRefPubMedGoogle Scholar
  45. 45.
    Castellon SA, Ganz PA, Bower JE, Petersen L, Waddell K, Greendale G: Neurocognitive performance among breast cancer survivors: impact of treatment, reproductive factors, and mood. Paper presented at the 40th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA., 2004. Abstract appears in American Society of Clinical Oncology Proceedings, 2004.Google Scholar
  46. 46.
    Tannock, IF, Ahles, TA, Ganz, PA, Dam, FS 2004Cognitive impairment associated with chemotherapy for cancer: report of a workshopJ Clin Oncol2222332239CrossRefPubMedGoogle Scholar
  47. 47.
    Ganz, PA, Kwan, L, Stanton, AL, Krupnick, JL, Rowland, JH, Meyerowitz, BE, Bower, JE, Belin, TR 2004Quality of life at the end of primary treatment of breast cancer: first results from the moving beyond cancer randomized trialJ Natl Cancer Inst96376387PubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Steven A. Castellon
    • 1
    • 2
    • 6
  • Daniel H. S. Silverman
    • 3
  • Patricia A. Ganz
    • 4
    • 5
  1. 1.Greater Los Angeles VA Healthcare SystemUSA
  2. 2.Dept. of Psychiatry and Biobehavioral SciencesDavid Geffen School of Medicine at UCLAUSA
  3. 3.Dept. of Molecular and Medical PharmacologyDavid Geffen School of Medicine at UCLAUSA
  4. 4.Division of Cancer Prevention and Control ResearchJonsson Comprehensive Cancer CenterUSA
  5. 5.Schools of Medicine and Public HealthUniversity of California Los AngelesUSA
  6. 6.Neuropsychiatric Institute & HospitalDavid Geffen School of Medicine at UCLALos AngelesUSA
  7. 7.David Geffen School of Medicine at UCLANeuropsychiatric Institute & HospitalLos AngelesUSA

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