Breast Cancer Research and Treatment

, Volume 87, Issue 3, pp 273–276

Loss of heterozygosity at BRCA2 in a ductal carcinoma in situ and three invasive breast carcinomas in a family with a germline BRCA2 mutation

  • Mads Thomassen
  • Torben A. Kruse
  • Karen Ege Olsen
  • A. Borg
  • Anne Marie Gerdes
Article

DOI: 10.1007/s10549-004-9503-3

Cite this article as:
Thomassen, M., Kruse, T.A., Olsen, K.E. et al. Breast Cancer Res Treat (2004) 87: 273. doi:10.1007/s10549-004-9503-3

Abstract

We have examined a family with a germline BRCA2 mutation in three cases of invasive breast cancer and one case of ductal carcinoma in situ (DCIS). Loss of heterozygosity (LOH) has been demonstrated at the BRCA2 locus in all cases. This result may suggest that the germline mutation in BRCA2 is the initiating step of DCIS and support the theory that DCIS is a precursor of invasive breast carcinoma in hereditary breast cancer.

BRCA2 breast cancer DCIS hereditary cancer LOH 

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Mads Thomassen
    • 1
  • Torben A. Kruse
    • 1
  • Karen Ege Olsen
    • 2
  • A. Borg
    • 3
  • Anne Marie Gerdes
    • 1
  1. 1.Department of Clinical Genetics and Clinical Biochemistry, KKAOdense University HospitalDenmark
  2. 2.Department of PathologyOdense University HospitalDenmark
  3. 3.Department of OncologyUniversity HospitalSweden

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