Metaplastic breast carcinoma: clinical–pathologic characteristics and HER2/neu expression
- 382 Downloads
Background. Metaplastic breast carcinomas (MBC) are rare primary breast malignancies characterized by the co-existence of carcinoma with non-epithelial cellular elements. They can be classified as monophasic spindle cell (sarcomatoid) carcinoma, biphasic carcinosarcoma, adenocarcinoma with divergent stromal differentiation (osseous, chondroid and rarely rhabdoid) as well as adenosquamous and pure squamous cell carcinomas. There is a paucity of information on clinically relevant pathologic features and clinical outcomes for these rare tumors. The aim of this study was to review the pathologic features and clinical outcomes of all cases of MBC seen at a single institution between 1971 and 2000.
Methods. A computerized search of the Queen Elizabeth II Health Sciences Center (QEII HSC) surgical pathology files was performed for the years 1971–2000. Tumor blocks from identified cases were reviewed and immunohistochemistry was performed for estrogen and progesterone receptors (ER/PR), HER2/neu protein overexpression and cytokeratin profile. Clinical outcome information was obtained from hospital files and telephone contact with treating physicians.
Results. Twenty-six (26) cases were retrieved with only one case identified before 1990. All tumors were high grade with a median tumor size of 3.7 cm (range 1.4–9.5 cm). Thirteen cases had lymph node dissections available for evaluation, with 4 demonstrating nodal metastases. Five of 26 cases were ER positive within the adenocarcinomatous component, only two of which also expressed PR. Associated ductal carcinoma in situ (DCIS) was present in 11 cases. HER2/neu over-expression was seen in only one (1/26) adenosquamous carcinoma (3 + membranous staining of the malignant glandular component). At 23 months median follow-up, disease free survival (DFS) for the entire group was 53%.
Conclusions. Although a rare breast cancer subtype, MBC is of considerable interest due to its pathological heterogeneity and differences in clinical behavior compared to typical breast carcinomas. Increasing pathologic recognition of MBC as a discrete entity is suggested by the number of MBC diagnoses in the last decade compared to previous years. The poor DFS associated with MBC suggests that further research exploring mechanisms of carcinogenesis and identifying clinically relevant prognostic factors is needed to direct optimum clinical care. Importantly, MBC variants appear to rarely overexpress the HER2/neu oncoprotein.
Keywordsbreast cancer HER2/neu metaplastic
Unable to display preview. Download preview PDF.
- 1.Tavassoli, FA 1992Classification of metaplastic carcinomas of the breastPathol Annual 27 Pt289119Google Scholar
- 2.Rosen, PP 1997Rosen’s Breast PathologyLippencott-RavenPhiladelphia375395Google Scholar
- 3.Elston, CW, Ellis, IO 1998The BreastChurchill LivingstoneEdinburg323330Google Scholar
- 8.Harris, JR, Hellmann, S. 1996
Natural history of breast cancerHarris, JRLippmann, MEMorrow, MHellmann, S eds. Diseases of the BreastLippencott-RavenPA Philadelphia375391Google Scholar
- 9.Rayson, D, Adjei, AA, Suman, VJ, et al. 1999Metaplastic breast cancer: Prognosis and response to systemic therapyAnnals of Oncol10413419Google Scholar
- 10.Elston, CW, Ellis, IO 1991Pathologic prognostic factors in breast cancerThe value of histologic grade in breast cancer. Experience from a large study with long term follow-up. Histopathology19403410Google Scholar
- 12.Foschini, MP, Dina, RE, Eusebi, V. 1993Sarcomatoid neoplasms of the breast: proposed definitions for biphasic and monophasic sarcomatoid mammary carcinomasSeminars in Diag Pathol10128136Google Scholar
- 14.Weidner, N. 1995Malignant breast lesions that may mimic benign tumorsSeminars in Diagn Pathol12213Google Scholar
- 18.Eusabi, V, Cattan, MG, Ceccarelli, C, et al. 1989Sarcomatoid carcinoma of the breast: an immunocytochemical study of 14 casesProg Surg Pathol108399Google Scholar
- 25.Hanna, W, O’Malley, FP 2002Updated recommendations from the HER2/neu consensus meeting- Toronto, Ontario, September 2001Current Oncol9s18s20Google Scholar