Breast Cancer Research and Treatment

, Volume 91, Issue 1, pp 29–34 | Cite as

Effect of perductal paclitaxel exposure on the development of MNU-induced mammary carcinoma in female S–D rats

  • Homa Okugawa
  • Daigo YamamotoEmail author
  • Yoshiko Uemura
  • Noriko Sakaida
  • Akihide Tanano
  • Kanji Tanaka
  • Yasuo Kamiyama


Background. Breast carcinoma and precancer are thought to start in the lining of the milk duct or lobule.

Methods. At 5weeks of age, rats received a intraperitoneal (ip) injection of MNU for carcinogenesis. After mammary tumors were identified macroscopically using fiberscope, the rats were treated with perductal (pd) or ip injection of paclitaxel tri-weekly. At 36 weeks after MNU injection, tumor burden (No. of >1cm palpable mammary tumors/rat), total number of mammary carcinoma, apoptosis (AI), and microvessel density (MVD) were measured.

Results. The administration of paclitaxel through the duct did not produce any toxic side effect. The tumor burden and total number of mammary carcinoma in the pd paclitaxel-treated group were significantly reduced compared to those seen in the ip paclitaxel-treated group. In addition, in the pd paclitaxel-treated group, AI was also increased and MVD was decreased, compared to those in the ip paclitaxel-treated group.

Conclusion. Local administration of paclitaxel may be useful for treatment of breast cancer.


fiberoptic ductoscopy paclitaxel mammary carcinoma 


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Copyright information

© Springer 2005

Authors and Affiliations

  • Homa Okugawa
    • 1
    • 2
  • Daigo Yamamoto
    • 1
    Email author
  • Yoshiko Uemura
    • 2
  • Noriko Sakaida
    • 2
  • Akihide Tanano
    • 1
  • Kanji Tanaka
    • 1
  • Yasuo Kamiyama
    • 1
  1. 1.Department of SurgeryKansai Medical UniversityMoriguchiJapan
  2. 2.Department of Clinical PathologyKansai Medical UniversityMoriguchiJapan

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