Breast Cancer Research and Treatment

, Volume 90, Issue 3, pp 299–305 | Cite as

Accuracy of breast screening among women with and without a family history of breast and/or ovarian cancer

  • Erika Halapy
  • Anna M. Chiarelli
  • Neil Klar
  • Julia A. Knight
Article

Summary

Objectives

To compare interval cancer rates, sensitivity and specificity of breast cancer screening between women with moderate or strong family history and women without a family history.

Methods

From 1996 to 1997, 115,460 women aged 50 to 69 screened by the Ontario Breast Screening Program, offering eligible women screening with mammography and clinical breast examination, were examined. Women were followed for up to 12 months after their screening examination. Family history definitions were based on the number of affected first degree relatives and their ages at diagnosis. Multivariate analysis was conducted to adjust for potential confounding variables.

Results

Interval cancer rates increased across family history groups and were greatest in women with a strong family history. The rate ratio (RR) for interval cancer rate in women with a strong family history compared to women without a family history approached significance (RR=2.28, 95% confidence interval (CI) 0.97–5.34), while for women with a moderate family history it did not (RR=1.37, 95% CI 0.62–3.04). A slightly but not significantly lower sensitivity was observed in women with a strong family history compared to women without a family history. There was little variation in specificity across family history groups.

Conclusions

Screening was able to detect a large proportion of invasive breast cancers in women with a family history, indicating their potential to benefit from regular breast cancer screening. However, due to increased interval cancer rates, screening with one-year intervals may be important even in an older population of women with a family history.

Keywords

breast cancer family history interval cancer rate screening sensitivity specificity 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Erika Halapy
    • 1
  • Anna M. Chiarelli
    • 1
    • 3
  • Neil Klar
    • 1
    • 3
  • Julia A. Knight
    • 2
    • 3
  1. 1.Division of Preventive OncologyCancer Care OntarioTorontoCanada
  2. 2.Samuel Lunenfeld Research InstituteMount Sinai HospitalCanada
  3. 3.Department of Public Health SciencesUniversity of TorontoTorontoCanada

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