Towards a Universal Taxonomy of Macro-scale Functional Human Brain Networks
The past decade has witnessed a proliferation of studies aimed at characterizing the human connectome. These projects map the brain regions comprising large-scale systems underlying cognition using non-invasive neuroimaging approaches and advanced analytic techniques adopted from network science. While the idea that the human brain is composed of multiple macro-scale functional networks has been gaining traction in cognitive neuroscience, the field has yet to reach consensus on several key issues regarding terminology. What constitutes a functional brain network? Are there “core” functional networks, and if so, what are their spatial topographies? What naming conventions, if universally adopted, will provide the most utility and facilitate communication amongst researchers? Can a taxonomy of functional brain networks be delineated? Here we survey the current landscape to identify six common macro-scale brain network naming schemes and conventions utilized in the literature, highlighting inconsistencies and points of confusion where appropriate. As a minimum recommendation upon which to build, we propose that a scheme incorporating anatomical terminology should provide the foundation for a taxonomy of functional brain networks. A logical starting point in this endeavor might delineate systems that we refer to here as “occipital”, “pericentral”, “dorsal frontoparietal”, “lateral frontoparietal”, “midcingulo-insular”, and “medial frontoparietal” networks. We posit that as the field of network neuroscience matures, it will become increasingly imperative to arrive at a taxonomy such as that proposed here, that can be consistently referenced across research groups.
KeywordsCoactivation Functional connectivity Human connectome Network neuroscience
LQU is supported by the National Institute of Mental Health (R01MH107549), the Canadian Institute for Advanced Research, and a University of Miami Gabelli Senior Scholar Award. RNS is supported by the Natural Sciences and Engineering Research Council of Canada and Canadian Institutes of Health Research, and is a Research Scholar supported by Fonds de recherche du Québec – Santé. BTTY is supported by the Singapore National Research Foundation (NRF) Fellowship (Class of 2017). The authors gratefully acknowledge Roberto Toro and Evan Gordan for assistance with figures.
- Cui Z, Li H, Xia CH, et al (2019) Individual variation in control network topography supports executive function in youthGoogle Scholar
- Dohmatob E, Dumas G, Bzdok D (2018) Dark control: towards a unified account of default mode function by Markov decision processesGoogle Scholar
- Lurie D, Kessler D, Bassett D et al (2018) On the nature of resting fMRI and time-varying functional connectivityGoogle Scholar
- Murphy AC, Bertolero MA, Papadopoulos L et al (2019) Multiscale and multimodal network dynamics underpinning working memoryGoogle Scholar
- Preti MG, Van De Ville D (2017) Dynamics of functional connectivity at high spatial resolution reveal long-range interactions and fine-scale organization. Sci Rep 7Google Scholar
- Talairach J, Tournoux P (1988) Co-planar stereotaxic atlas of the human brain. Theime, New YorkGoogle Scholar
- Uddin LQ (2016) Salience network of the human brain. Academic Press, CambridgeGoogle Scholar
- Urchs S, Armoza J, Moreau C et al (2019) MIST: a multi-resolution parcellation of functional brain networks. MNI Open ResGoogle Scholar