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Brain Topography

, Volume 32, Issue 2, pp 295–303 | Cite as

Aberrant Intrinsic Brain Activity in Patients with Autism Spectrum Disorder: Insights from EEG Microstates

  • Huibin Jia
  • Dongchuan YuEmail author
Original Paper

Abstract

Autism spectrum disorder (ASD) involves aberrant organization and functioning of large-scale brain networks. The aim of this study was to examine whether the resting-state EEG microstate analysis could provide novel insights into the abnormal temporal and spatial properties of intrinsic brain activities in patients with ASD. To achieve this goal, EEG microstate analysis was conducted on the resting-state EEG datasets of 15 patients with ASD and 18 healthy controls from the Healthy Brain Network. The parameters (i.e., duration, occurrence rate, time coverage and topographical configuration) of four classical microstate classes (i.e., class A, B, C and D) were statistically tested between two groups. The results showed that: (1) the occurrence rate and time coverage of microstate class B in ASD group were significantly larger than those in control group; (2) the duration of microstate class A, the duration and time coverage of microstate class C were significantly smaller than those in control group; (3) the map configuration and occurrence rate differed significantly between two groups for microstate class D. These results suggested that EEG microstate analysis could be used to detect the deviant functions of large-scale cortical activities in ASD, and may provide indices that could be used in clinical researches of ASD.

Keywords

Microstates parameter Resting-state network Phonological processing Self-representation 

Notes

Acknowledgements

The work was supported by the National Natural Science Foundation of China (CN) under Grants 61673113, 61273224, and 61074126. Funding sources had no involvement in any aspect of study design, data analysis, or manuscript preparation.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interests.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Key Laboratory of Child Development and Learning Science of Ministry of Education, Research Center for Learning Science, School of Biological Sciences & Medical EngineeringSoutheast UniversityNanjingChina

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