Brain Topography

, Volume 32, Issue 2, pp 271–282 | Cite as

Abnormal Functional Connectivity Density in Post-Stroke Aphasia

  • Jing Guo
  • Mi YangEmail author
  • Bharat B. Biswal
  • Pu Yang
  • Wei Liao
  • Huafu ChenEmail author
Original Paper


Post-stroke aphasia (PSA), which refers to the loss or impairment of language, is typically caused by left hemisphere lesions. Previous neuroimaging studies have indicated that the pathology of PSA may be related to abnormalities in functional integration. In this study, we used resting-state functional magnetic resonance imaging (rs-fMRI) to examine functional connectivity density (FCD) in PSA. We compared short- and long-range FCD between individuals with PSA (n = 17) and healthy controls (HC, n = 20). We then performed Pearson’s correlation analysis on the FCD values from the affected brain regions and the speech scores in the PSA group. Compared with HCs, individuals with PSA showed increased short-range FCD in the contralesional temporal gyrus, the inferior frontal gyrus, the thalamus, the insula, and the mesial temporal gyrus [hippocampus/parahippocampus (HIP/ParaHIP)]. PSA demonstrated an increased long-range FCD in the contralesional mesial temporal gyrus (HIP/ParaHIP). PSA also displayed decreased short-range FCD in the ipsilesional part of the frontal gyrus, the caudate, the thalamus, the fusiform gyrus, and the mesial temporal gyrus (HIP/ParaHIP), and decreased long-range FCD in the ipsilesional superior temporal gyrus, the fusiform gyrus, and the mesial temporal gyrus (HIP/ParaHIP). The decreased long-range FCD in the left superior temporal gyrus in PSA subjects was positively correlated with the spontaneous speech score. The altered FCD observed due to disrupted functional connectivity after stroke may lead to language production, semantic processing, and cognitive impairments. Our findings expand previous functional studies on stroke and provide new evidence of the intraregional and interregional interactions at the voxel level in the pathophysiology of PSA.


Post-stroke aphasia Resting-state functional magnetic resonance imaging Functional connectivity density 



Post-stroke aphasia


Functional magnetic resonance imaging


Functional connectivity density


Aphasia battery of Chinese


Aphasia quotient


Performance quotient


Cortical quotient


Functional connectivity



We thank the radiologist Ying Liu (Y.L.) from the Hospital of Fuzhou for manually tracing the outline of the lesion. This work was supported by Natural Science Foundation of China (Grant Nos. 61806042 and 81471653), Fundamental Research Funds for the Central University (Grant No. ZYGX2013Z004), Sichuan provincial health and family planning commission research project (Grant No. 16PJ051), and the project of the Science and Technology Department in Sichuan province (Grant No. 2017JY0094).

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10548_2018_681_MOESM1_ESM.docx (198 kb)
Supplementary material 1 (DOCX 197 KB)


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Authors and Affiliations

  1. 1.MOE Key Lab for Neuroinformation, The Clinical Hospital of Chengdu Brain Science InstituteUniversity of Electronic Science and Technology of ChinaChengduChina
  2. 2.School of MedicineUniversity of Electronic Science and Technology of ChinaChengduChina
  3. 3.School of Life Science and Technology, Center for Information in MedicineUniversity of Electronic Science and Technology of ChinaChengduChina
  4. 4.Department of Biomedical EngineeringNew Jersey Institute of TechnologyNewarkUSA

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