Brain Topography

, Volume 32, Issue 3, pp 394–404 | Cite as

Altered Dynamic Functional Network Connectivity in Frontal Lobe Epilepsy

  • Benjamin Klugah-Brown
  • Cheng LuoEmail author
  • Hui He
  • Sisi Jiang
  • Gabriel Kofi Armah
  • Yu Wu
  • Jianfu Li
  • Wenjie Yin
  • Dezhong Yao
Original Paper


Frontal lobe epilepsy has recently been associated with disrupted brain functional connectivity; variations among various resting-state networks (RSNs) across time remains largely unclear. This study applied dynamic functional network connectivity (dFNC) analysis to investigate functional patterns in the temporal and spatial domains of various functional systems in FLE. Resting-state fMRI data were acquired from 19 FLE patients and 18 controls. Independent component analysis was used to decompose RSNs, which were grouped into seven functional systems. Sliding windows and clustering approach were used to identify the dFNC patterns. Then, state-specific connectivity pattern and dynamic functional state interactions (dFSIs) were evaluated. Compared with healthy controls, FLE patients exhibited decreased dFNC in almost all four patterns, changes that were mostly related to the frontoparietal system, suggesting a disturbed communication of the frontoparietal system with other systems in FLE. Additionally, regarding the fundamental connectivity pattern (state 3 in this study), FLE showed decreased time spent in this state. Moreover, the duration positively correlated with seizure onset. Furthermore, significantly reduced dynamic connections in this state were observed in the frontoparietal system linked to the cerebellar and subcortical systems. These findings imply abnormal fundamental dynamic interactions and dysconnectivity associated with the subcortical and cerebellar regulation of dysfunctions in frontoparietal regions in FLE. Finally, based on the developed FSI analysis, temporal dynamic abnormalities among states were observed in FLE. Therefore, this altered dynamic FNC extended our understanding of the abnormalities in the frontoparietal system in FLE. The dynamic FNC provided novel insight into the fundamental pathophysiological mechanisms in FLE.


Frontal lobe epilepsy Dynamic functional network connectivity Dynamic functional state interaction Resting-state fMRI Double regression 



This work was supported by grants from the National Nature Science Foundation of China (Grant Nos. 81771822, 81471638 and 81330032); The Project of Science and Technology Department of Sichuan Province (Nos. 2017SZ0004 and 2017HH0001); and the ‘111’ project of China (Grant No. B12027). We thank Dr. Jiang and Dr. Wang for their help in collecting data.

Compliance with Ethical Standards

Conflict of interest

None of the authors had any conflicts of interest to disclose. We confirm that we have read the Journal’s position on the issues involved in ethical publication and affirm that this report is consistent with those guidelines.

Supplementary material

10548_2018_678_MOESM1_ESM.docx (6.9 mb)
Supplementary material 1 (DOCX 7043 KB)


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Benjamin Klugah-Brown
    • 1
  • Cheng Luo
    • 1
    Email author
  • Hui He
    • 1
  • Sisi Jiang
    • 1
  • Gabriel Kofi Armah
    • 2
  • Yu Wu
    • 3
  • Jianfu Li
    • 1
  • Wenjie Yin
    • 3
  • Dezhong Yao
    • 1
  1. 1.The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technologyUniversity of Electronic Science and Technology of ChinaChengduPeople’s Republic of China
  2. 2.Navrongo Campus, Computer Science DepartmentUniversity for Development studiesTamaleGhana
  3. 3.Department of RadiologyChengdu First People’s HospitalChengduPeople’s Republic of China

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