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Brain Topography

, Volume 30, Issue 4, pp 539–547 | Cite as

Electroencephalographic Evidence of Altered Top–Down Attentional Modulation in Fibromyalgia Patients During a Working Memory Task

  • Alberto J. González-VillarEmail author
  • Marina Pidal-Miranda
  • Manuel Arias
  • Dolores Rodríguez-Salgado
  • María T. Carrillo-de-la-Peña
Original Paper

Abstract

Fibromyalgia (FM) is a chronic syndrome involving widespread pain of unclear pathophysiology. FM patients frequently complain about cognitive symptoms that interfere with their daily life activities. Several studies have reported attentional deficits and working memory impairment in FM patients. Nevertheless, the mechanisms involved in these alterations are still poorly understood. In this study we recorded electroencephalographic activity in 32 women with FM and 30 matched controls while they performed a 2-back working memory task. We analyzed behavioural data, posterior alpha and midfrontal theta frequency power, and theta phase synchronization between midfrontal locations and the remaining scalp-recorded areas. Task performance was similar in patients and controls; however, time–frequency analysis showed a smaller decrease in the amplitude of the posterior alpha (related to attentional processing) and a smaller increase in midfrontal theta power (related to mental effort) in FM patients than in healthy controls. The FM patients also showed lower functional connectivity between midfrontal locations and rest of the scalp-recorded areas in the theta band (related to information transfer across distant brain regions when top-down control is required). To our knowledge, this is the first study relating alterations in oscillatory activity and impaired connectivity to attentional working memory complaints in FM patients. Reduced power in the theta band during performance of the task suggests that the medial frontal cortex may play an important role in the attentional deficits reported in FM.

Keywords

Fibromyalgia Working memory n-Back Attention Theta Alpha 

Notes

Funding

This work was supported by funding from the Galician Government (Consellería de Cultura, Educación e Ordenación Universitaria; axudas para a consolidación e Estruturación de unidades de investigación competitivas do Sistema universitario de Galicia [grant number GPC2014/047] and funding from the Spanish Government (Ministerio de Economía y Competitividad) [Grant Number PSI2013-45818-R]. A.G.V. was supported by a grant from the Fundación Ramón Domínguez.

Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Supplementary material

10548_2017_561_MOESM1_ESM.docx (14 kb)
Supplementary material 1 (DOCX 13 KB)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Alberto J. González-Villar
    • 1
    Email author
  • Marina Pidal-Miranda
    • 1
  • Manuel Arias
    • 2
  • Dolores Rodríguez-Salgado
    • 1
  • María T. Carrillo-de-la-Peña
    • 1
  1. 1.Department of Clinical Psychology and PsychobiologyUniversidade de Santiago de CompostelaSantiago de CompostelaSpain
  2. 2.Department of NeurologyComplexo Hospitalario Universitario de SantiagoSantiago de CompostelaSpain

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